University thesis:
Dissertation, Georg-August-Universität Göttingen, 2017
Footnote:
Description:
Aβ4-42 is one of the major variants of beta-amyloid (Aβ) in the Alzheimer brain and one of the earliest to appear in the development of the disease. It shows an increased aggregation tendency and toxicity. Furthermore it has been shown previously, that Aβ4-42 also affects brain functions and induces cognitive impairments in vivo after intraventricular injection to the brain of wildtype mice and in Tg4-42 mice. These mice carry a transgene for an enhanced expression of Aβ4-42 and develop a severe neuron loss in the CA1 region of the hippocampus that correlates with age-dependent memory defic...