University thesis:
Dissertation, Georg-August-Universität Göttingen, 2016
Footnote:
Description:
Psychiatric diseases such as schizophrenia, bipolar disorder and autism spectrum disorders are considered neurodevelopmental synaptopathies. Compelling evidence obtained from large-scale genome-wide association studies, identified a plethora of genetic variations within hundreds of genes encoding components of the post-synaptic compartment and calcium signaling mediating excitation-transcription-coupling. This synapse-to-nucleus signaling is thought to be particularly important for synaptic plasticity and learning and memory. In the last decade, tremendous progress has been made in neurosci...