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Media type:
Electronic Thesis;
E-Book
Title:
Guanylate cyclase-activating protein 5 from the zebrafish retina binds ferrous iron and is a redox-sensitive regulator of retinal guanylate cyclases
Contributor:
Menke-Sell, Sarah-Karina
[Author]
Published:
Carl von Ossietzky Universität Oldenburg: /oops/ - Oldenburger Online-Publikations-Server, 2023
Footnote:
Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
Description:
Guanylate cyclase-activating proteins (GCAPs) are neuronal calcium sensors that activate retinal guanylate cyclases (GCs) in a Ca2+-dependent manner. GCAP5 from the retina of the zebrafish (Danio rerio) harbors a non-conserved cysteine cluster at its N-terminal. C15 and C17 prevent a Ca2+-dependent conformational change essential for a Ca2+-dependent regulation of retinal GCs. In exchange, they mediate redox-sensitive regulation. Further, GCAP5 binds ferrous iron with nanomolar affinity (Lim et al. 2017, Biochemistry 56(51): 6652-6661): Two GCAP5 molecules coordinate one ferrous iron with C15 and C17, forming an iron-sulfur cluster in a [Fe(SCys)4] complex. These unusual characteristics of GCAP5 lead to the conclusion that it might be involved in cell protection under oxidative stress conditions.