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Knoedler, Samuel [Author]; Kauke-Navarro, Martin [Author]; Knoedler, Leonard [Author]; Friedrich, Sarah [Author]; Matar, Dany Y. [Author]; Diatta, Fortunay [Author]; Mookerjee, Vikram G. [Author]; Ayyala, Haripriya [Author]; Wu, Mengfan [Author]; Kim, Bong-Sung [Author]; Machens, Hans-Guenther [Author]; Pomahac, Bohdan [Author]; Orgill, Dennis P. [Author]; Broer, P. Niclas [Author]; Panayi, Adriana C. [Author]

Racial disparities in surgical outcomes after mastectomy in 223 000 female breast cancer patients: a retrospective cohort study

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  • Media type: E-Article
  • Title: Racial disparities in surgical outcomes after mastectomy in 223 000 female breast cancer patients: a retrospective cohort study
  • Contributor: Knoedler, Samuel [Author]; Kauke-Navarro, Martin [Author]; Knoedler, Leonard [Author]; Friedrich, Sarah [Author]; Matar, Dany Y. [Author]; Diatta, Fortunay [Author]; Mookerjee, Vikram G. [Author]; Ayyala, Haripriya [Author]; Wu, Mengfan [Author]; Kim, Bong-Sung [Author]; Machens, Hans-Guenther [Author]; Pomahac, Bohdan [Author]; Orgill, Dennis P. [Author]; Broer, P. Niclas [Author]; Panayi, Adriana C. [Author]
  • Published: Augsburg University Publication Server (OPUS), 2024
  • Language: English
  • DOI: https://doi.org/10.1097/js9.0000000000000909
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: Background: Breast cancer mortality and treatment differ across racial groups. It remains unclear whether such disparities are also reflected in perioperative outcomes of breast cancer patients undergoing mastectomy. Study design: The authors reviewed the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database (2008–2021) to identify female patients who underwent mastectomy for oncological purposes. The outcomes were stratified by five racial groups (white, Black/African American, Asian, American Indian/Alaska Native, and Native Hawaiian/Pacific Islander) and included 30-day mortality, reoperation, readmission, surgical and medical complications, and non-home discharge. Results: The study population included 222 947 patients, 68% (n=151 522) of whom were white, 11% (n=23 987) Black/African American, 5% (n=11 217) Asian, 0.5% (n=1198) American Indian/Alaska Native, and 0.5% (n=1018) Native Hawaiian/Pacific Islander. While 136 690 (61%) patients underwent partial mastectomy, 54 490 (24%) and 31 767 (14%) women received simple and radical mastectomy, respectively. Overall, adverse events occurred in 17 222 (7.7%) patients, the largest portion of which were surgical complications (n=7246; 3.3%). Multivariable analysis revealed that being of Asian race was protective against perioperative complications [odds ratio (OR)=0.71; P<0.001], whereas American Indian/Alaska Native women were most vulnerable to the complication occurrence (OR=1.41; P<0.001). Black/African American patients had a significantly lower risk of medical (OR=0.59; P<0.001) and surgical complications (OR=0.60; P<0.001) after partial and radical mastectomy, respectively, their likelihood of readmission (OR=1.14; P=0.045) following partial mastectomy was significantly increased. Conclusion: The authors identified American Indian/Alaska Native women as particularly vulnerable to complications following mastectomy. Asian patients experienced the lowest rate of complications in the perioperative period. ...
  • Access State: Open Access