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Koeder, Christian [Author]; Anand, Corinna [Author]; Husain, Sarah [Author]; Kranz, Ragna-Marie [Author]; Schoch, Nora [Author]; Alzughayyar, Dima [Author]; Bitterlich, Norman [Author]; Hahn, Andreas [Author]; Englert, Heike [Author]

Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers – the Healthy Lifestyle Community Programme (cohort 2) - [published Version]

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  • Media type: Text; E-Article
  • Title: Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers – the Healthy Lifestyle Community Programme (cohort 2)
  • Contributor: Koeder, Christian [Author]; Anand, Corinna [Author]; Husain, Sarah [Author]; Kranz, Ragna-Marie [Author]; Schoch, Nora [Author]; Alzughayyar, Dima [Author]; Bitterlich, Norman [Author]; Hahn, Andreas [Author]; Englert, Heike [Author]
  • imprint: London : BioMed Central, 2023
  • Published in: BMC nutrition 9 (2023) ; BMC nutrition
  • Issue: published Version
  • Language: English
  • DOI: https://doi.org/10.15488/13350; https://doi.org/10.1186/s40795-023-00684-2
  • Keywords: Homocysteine ; Lifestyle intervention ; Plant-based diet ; C-reactive protein ; Subclinical inflammation ; Cardiovascular disease ; Adiponectin
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  • Description: Background: Chronic low-grade inflammation is associated with an increased risk of chronic disease and mortality. The objective of the study was to test the effect of a healthy lifestyle intervention on biomarkers of inflammation (among other risk markers). Methods: We conducted a non-randomized controlled trial with mostly middle-aged and elderly participants from the general population in rural northwest Germany (intervention: n = 114; control: n = 87). The intervention consisted of a 1-year lifestyle programme focusing on diet (largely plant-based; strongest emphasis), physical activity, stress management, and social support. High-sensitivity C-reactive protein (hs-CRP) was assessed at baseline, 10 weeks, 6 months, and 1 year. Homocysteine (Hcy) was assessed at baseline, 10 weeks, and 1 year. Adiponectin (Apn) was assessed at baseline and 10 weeks. An exploratory analysis of these inflammatory markers assessing the between-group differences with ANCOVA was conducted. Results: The 1-year trajectory of hs-CRP was significantly lower in the intervention group compared to control (between-group difference: -0.8 (95% CI -1.2, -0.3) mg/l; p = 0.001; adjusted for baseline). The 1-year trajectory of Hcy was non-significantly higher in the intervention compared to control (between-group difference: 0.2 (95% CI -0.3, 0.7) µmol/l; p = 0.439; adjusted for baseline). From baseline to 10 weeks, Apn decreased significantly more in the intervention group compared to control (between-group difference: -1.6 (95% CI -2.7, -0.5) µg/ml; p = 0.004; adjusted for baseline). Conclusions: Our study shows that healthy lifestyle changes can lower hs-CRP and Apn levels and are unlikely to significantly affect Hcy levels within 1 year. Trial registration: German Clinical Trials Register (DRKS; reference: DRKS00018775, registered 12 Sept 2019; retrospectively registered; www.drks.de).
  • Access State: Open Access
  • Rights information: Attribution (CC BY)