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Matena, Julia [Author]; Petersen, Svea [Author]; Gieseke, Matthias [Author]; Kampmann, Andreas [Author]; Teske, Michael [Author]; Beyerbach, Martin [Author]; Murua Escobar, Hugo [Author]; Haferkamp, Heinz [Author]; Gellrich, Nils-Claudius [Author]; Nolte, Ingo [Author]

SLM produced porous titanium implant improvements for enhanced vascularization and osteoblast seeding - [published Version]

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  • Media type: Text; E-Article
  • Title: SLM produced porous titanium implant improvements for enhanced vascularization and osteoblast seeding
  • Contributor: Matena, Julia [Author]; Petersen, Svea [Author]; Gieseke, Matthias [Author]; Kampmann, Andreas [Author]; Teske, Michael [Author]; Beyerbach, Martin [Author]; Murua Escobar, Hugo [Author]; Haferkamp, Heinz [Author]; Gellrich, Nils-Claudius [Author]; Nolte, Ingo [Author]
  • imprint: Basel : MDPI AG, 2015
  • Published in: International Journal of Molecular Sciences 16 (2015), Nr. 4
  • Issue: published Version
  • Language: English
  • DOI: https://doi.org/10.15488/1595; https://doi.org/10.3390/ijms16047478
  • ISSN: 1422-0067
  • Keywords: 0 (Polyesters) ; Osteogenesis/drug effects ; Cell Movement/drug effects ; Titanium/administration & dosage ; Physiologic/drug effects ; Cell Adhesion/drug effects ; 0 (Polymers) ; Polymers/chemistry ; Surface Properties ; Blood Vessels/drug effects/metabolism ; Cells ; Chemokine CXCL12/metabolism ; D1JT611TNE (Titanium) ; Vascular Endothelial Growth Factor A/metabolism ; Mice ; 0 (Vascular Endothelial Growth Factor A) ; 0 (HMGB1 Protein) ; Freezing ; Lasers ; Endothelial Cells/drug effects/metabolism ; Neovascularization ; Prostheses and Implants ; Polyesters/chemistry ; 0 (Chemokine CXCL12) ; [...]
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  • Description: To improve well-known titanium implants, pores can be used for increasing bone formation and close bone-implant interface. Selective Laser Melting (SLM) enables the production of any geometry and was used for implant production with 250-microm pore size. The used pore size supports vessel ingrowth, as bone formation is strongly dependent on fast vascularization. Additionally, proangiogenic factors promote implant vascularization. To functionalize the titanium with proangiogenic factors, polycaprolactone (PCL) coating can be used. The following proangiogenic factors were examined: vascular endothelial growth factor (VEGF), high mobility group box 1 (HMGB1) and chemokine (C-X-C motif) ligand 12 (CXCL12). As different surfaces lead to different cell reactions, titanium and PCL coating were compared. The growing into the porous titanium structure of primary osteoblasts was examined by cross sections. Primary osteoblasts seeded on the different surfaces were compared using Live Cell Imaging (LCI). Cross sections showed cells had proliferated, but not migrated after seven days. Although the cell count was lower on titanium PCL implants in LCI, the cell count and cell spreading area development showed promising results for titanium PCL implants. HMGB1 showed the highest migration capacity for stimulating the endothelial cell line. Future perspective would be the incorporation of HMGB1 into PCL polymer for the realization of a slow factor release. ; DFG/299/11-1
  • Access State: Open Access
  • Rights information: Attribution (CC BY)