Rationale and plan for vitamin D food fortification: A review and guidance paper

Media type: E-Article; Text

Title: Rationale and plan for vitamin D food fortification: A review and guidance paper

Contributor: Pilz, Stefan [Author]; März, Winfried [Author]; Cashman, Kevin D. [Author]; Kiely, Mairead E. [Author]; Whiting, Susan J. [Author]; Holick, Michael F. [Author]; Grant, William B. [Author]; Pludowski, Pawel [Author]; Hiligsmann, Mickael [Author]; Trummer, Christian [Author]; Schwetz, Verena [Author]; Lerchbaum, Elisabeth [Author]; Pandis, Marlene [Author]; Tomaschitz, Andreas [Author]; Grübler, Martin R. [Author]; Gaksch, Martin [Author]; Verheyen, Nicolas [Author]; Hollis, Bruce W. [Author]; Rejnmark, Lars [Author]; Karras, Spyridon N. [Author]; Hahn, Andreas [Author]; Bischoff-Ferrari, Heike A. [Author]; Reichrath, Jörg [Author]; Jorde, Rolf [Author]; [...]

imprint: Lausanne : Frontiers Media S.A., 2018

Issue: published Version

Language: English

DOI: https://doi.org/10.15488/3733; https://doi.org/10.3389/fendo.2018.00373

Keywords: Vitamin D ; Public health ; Policy ; General population ; Guidelines ; Evidence ; Food fortification ; Recommendations

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Description: Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such as respiratory tract infections, asthma exacerbations, pregnancy complications and premature deaths. Vitamin D has a unique metabolism as it is mainly obtained through synthesis in the skin under the influence of sunlight (i.e., ultraviolet-B radiation) whereas intake by nutrition traditionally plays a relatively minor role. Dietary guidelines for vitamin D are based on a consensus that serum 25-hydroxyvitamin D (25[OH]D) concentrations are used to assess vitamin D status, with the recommended target concentrations ranging from ≥25 to ≥50 nmol/L (≥10-≥20 ng/mL), corresponding to a daily vitamin D intake of 10 to 20 μg (400-800 international units). Most populations fail to meet these recommended dietary vitamin D requirements. In Europe, 25(OH)D concentrations < 30 nmol/L (12 ng/mL) and < 50 nmol/L (20 ng/mL) are present in 13.0 and 40.4% of the general population, respectively. This substantial gap between officially recommended dietary reference intakes for vitamin D and the high prevalence of vitamin D deficiency in the general population requires action from health authorities. Promotion of a healthier lifestyle with more outdoor activities and optimal nutrition are definitely warranted but will not erase vitamin D deficiency and must, in the case of sunlight exposure, be well balanced with regard to potential adverse effects such as skin cancer. Intake of vitamin D supplements is limited by relatively poor adherence (in particular in individuals with low-socioeconomic status) and potential for overdosing. Systematic vitamin D food fortification is, however, an effective approach to improve vitamin D status in the general population, and this has already been introduced by countries such as the US, Canada, India, and Finland. Recent advances in our knowledge on the safety of vitamin D treatment, the dose-response relationship of vitamin D ...

Access State: Open Access

Rights information: Attribution (CC BY)

Rationale and plan for vitamin D food fortification: A review and guidance paper - [published Version]

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