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Pilz, Stefan [Author]; Zittermann, Armin [Author]; Obeid, Rima [Author]; Hahn, Andreas [Author]; Pludowski, Pawel [Author]; Trummer, Christian [Author]; Lerchbaum, Elisabeth [Author]; Pérez-López, Faustino R. [Author]; Karras, Spyridon N. [Author]; März, Winfried [Author]

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data - [published Version]

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  • Media type: Text; E-Article
  • Title: The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data
  • Contributor: Pilz, Stefan [Author]; Zittermann, Armin [Author]; Obeid, Rima [Author]; Hahn, Andreas [Author]; Pludowski, Pawel [Author]; Trummer, Christian [Author]; Lerchbaum, Elisabeth [Author]; Pérez-López, Faustino R. [Author]; Karras, Spyridon N. [Author]; März, Winfried [Author]
  • Published: Basel : MDPI, 2018
  • Published in: International Journal of Environmental Research and Public Health 15 (2018)
  • Issue: published Version
  • Language: English
  • DOI: https://doi.org/10.15488/3893
  • Keywords: 25-hydroxyvitamin D ; Vitamin D ; breast milk ; DBP ; vitamin D binding protein ; pre-eclampsia ; autism ; brain ; gestational diabetes
  • Origination:
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  • Description: Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)