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Shahraz, Anahita [Author]; Kopatz, Jens [Author]; Mathy, Rene [Author]; Kappler, Joachim [Author]; Winter, Dominic [Author]; Kapoor, Shoba [Author]; Schuetza, Vlad [Author]; Scheper, Thomas [Author]; Gieselmann, Volkmar [Author]; Neumann, Harald [Author]

Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages - [published Version]

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  • Media type: Text; E-Article
  • Title: Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages
  • Contributor: Shahraz, Anahita [Author]; Kopatz, Jens [Author]; Mathy, Rene [Author]; Kappler, Joachim [Author]; Winter, Dominic [Author]; Kapoor, Shoba [Author]; Schuetza, Vlad [Author]; Scheper, Thomas [Author]; Gieselmann, Volkmar [Author]; Neumann, Harald [Author]
  • imprint: London : Springer Nature, 2015
  • Published in: Scientific Reports 5 (2015)
  • Issue: published Version
  • Language: English
  • DOI: https://doi.org/10.15488/4861; https://doi.org/10.1038/srep16800
  • ISSN: 2045-2322
  • Keywords: Neuroimmunology ; Glycobiology
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: Oligosialic and polysialic acid (oligoSia and polySia) of the glycocalyx of neural and immune cells are linear chains, in which the sialic acid monomers are alpha 2.8-glycosidically linked. Sialic acid-binding immunoglobulin-like lectin-11 (SIGLEC-11) is a primate-lineage specific receptor of human tissue macrophages and microglia that binds to alpha 2.8-linked oligoSia. Here, we show that soluble low molecular weight polySia with an average degree of polymerization 20 (avDP20) interacts with SIGLEC-11 and acts anti-inflammatory on human THP1 macrophages involving the SIGLEC-11 receptor. Soluble polySia avDP20 inhibited the lipopolysaccharide (LPS)-induced gene transcription and protein expression of tumor necrosis factor-alpha (Tumor Necrosis Factor Superfamily Member 2, TNFSF2). In addition, polySia avDP20 neutralized the LPS-triggered increase in macrophage phagocytosis, but did not affect basal phagocytosis or endocytosis. Moreover, polySia avDP20 prevented the oxidative burst of human macrophages triggered by neural debris or fibrillary amyloid-beta(1-42). In a human macrophage-neuron co-culture system, polySia avDP20 also reduced loss of neurites triggered by fibrillary amyloid-beta(1-42). Thus, treatment with polySia avDP20 might be a new anti-inflammatory therapeutic strategy that also prevents the oxidative burst of macrophages.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)