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Roland, Laura [Author]; Backhaus, Samantha [Author]; Grau, Michael [Author]; Matena, Julia [Author]; Teske, Michael [Author]; Beyerbach, Martin [Author]; Escobar, Hugo Murua [Author]; Haferkamp, Heinz [Author]; Gellrich, Nils-Claudius [Author]; Nolte, Ingo [Author]

Evaluation of functionalized porous titanium implants for enhancing angiogenesis in vitro - [published Version]

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  • Media type: E-Article; Text
  • Title: Evaluation of functionalized porous titanium implants for enhancing angiogenesis in vitro
  • Contributor: Roland, Laura [Author]; Backhaus, Samantha [Author]; Grau, Michael [Author]; Matena, Julia [Author]; Teske, Michael [Author]; Beyerbach, Martin [Author]; Escobar, Hugo Murua [Author]; Haferkamp, Heinz [Author]; Gellrich, Nils-Claudius [Author]; Nolte, Ingo [Author]
  • imprint: Basel : MDPI AG, 2016
  • Published in: Materials 9 (2016), Nr. 4
  • Issue: published Version
  • Language: English
  • DOI: https://doi.org/10.15488/748; https://doi.org/10.3390/ma9040304
  • ISSN: 1996-1944
  • Keywords: Bioactivity ; Assays ; Defects ; Titanium ; HMGB1 ; Functionalized implants ; Bone ; Vascular endothelial growth factor ; Endothelial cells ; High-mobility groups ; Angiogenesis ; Angiogenic factor ; Functionalized ; PCL ; VEGF ; Porous titanium implants
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  • Description: Implant constructs supporting angiogenesis are favorable for treating critically-sized bone defects, as ingrowth of capillaries towards the center of large defects is often insufficient. Consequently, the insufficient nutritional supply of these regions leads to impaired bone healing. Implants with specially designed angiogenic supporting geometry and functionalized with proangiogenic cytokines can enhance angiogenesis. In this study, Vascular Endothelial Growth Factor (VEGF) and High Mobility Group Box 1 (HMGB1) were used for incorporation into poly-ε-caprolactone (PCL)-coated porous titanium implants. Bioactivity of released factors and influence on angiogenesis of functionalized implants were evaluated using a migration assay and angiogenesis assays. Both implants released angiogenic factors, inducing migration of endothelial cells. Also, VEGF-functionalized PCL-coated titanium implants enhanced angiogenesis in vitro. Both factors were rapidly released in high doses from the implant coating during the first 72 h. ; DFG/299/11-1
  • Access State: Open Access
  • Rights information: Attribution - Non Commercial - Share Alike (CC BY-NC-SA)