• Media type: Text; Report; E-Book
  • Title: On a diffuse interface model of tumor growth
  • Contributor: Frigeri, Sergio Pietro [Author]; Grasselli, Maurizio [Author]; Rocca, Elisabetta [Author]
  • Published: Weierstrass Institute for Applied Analysis and Stochastics publication server, 2014
  • Language: English
  • DOI: https://doi.org/10.20347/WIAS.PREPRINT.1956
  • Keywords: 92C17 ; 35K57 ; 37L30 ; diffuse interface -- tumor growth -- Cahn-Hilliard equations -- reaction-diffusion equations -- weak solutions -- well-posedness -- global attractors ; 35D30 ; 35Q92 ; article
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  • Description: We consider a diffuse interface model of tumor growth proposed by A. Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction &#966 nonlinearly coupled with a reaction-diffusion equation for &#968 which represents the nutrient-rich extracellular water volume fraction. The coupling is expressed through a suitable proliferation functionp(&#966) multiplied by the differences of the chemical potentials for &#966 and &#968. The system is equipped with no-flux boundary conditions which entails the conservation of the total mass, that is, the spatial average of &#966+&#968. Here we prove the existence of a weak solution to the associated Cauchy problem, provided that the potential F and p satisfy sufficiently general conditions. Then we show that the weak solution is unique and continuously depends on the initial data, provided that p satisfies slightly stronger growth restrictions. Also, we demonstrate the existence of a strong solution and that any weak solution regularizes in finite time. Finally, we prove the existence of the global attractor in a phase space characterized by an a priori bounded energy.
  • Access State: Open Access