• Media type: Report; E-Book
  • Title: Improving the Availability of Unrelated Stem Cell Donors: Evidence from a Major Donor Registry
  • Contributor: Haylock, Michael [Author]; Kampkötter, Patrick [Author]; Macis, Mario [Author]; Sauter, Jürgen [Author]; Seitz, Susanne [Author]; Slonim, Robert [Author]; Wiesen, Daniel [Author]; Schmidt, Alexander H. [Author]
  • imprint: Bonn: Institute of Labor Economics (IZA), 2022
  • Language: English
  • Keywords: intention-to-treat ; local average treatment effects ; unrelated stem cell donation ; I12 ; I18 ; donor availability ; sorting ; registry initiatives
  • Origination:
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  • Description: The unavailability of potential stem cell donors poses a critical challenge for donor registries worldwide. This study investigates the impact of initiatives of a stem cell donor registry to enhance donors' availability for confirmatory typing. Initiatives ask donors to provide a sample for genetic analysis and/or information on their temporal unavailability. We analyzed 91,479 confirmatory typing requests from DKMS Germany, a large stem cell donor registry, exploiting a quasi-random initiative assignment based on observable characteristics. We find that, first, invitation to the initiatives increases donors' availability. Intention-to-treat estimates yield effects ranging from 2.5 to 3.2 percentage points, and local average treatment effects estimates range from 3.8 to 8.2 percentage points ( baseline: 77.1%). Second, the difference in availability between participants and non-participants is over 10 percentage points. The initiatives yield a direct positive effect on donor availability and a selection effect through which participation signals a higher commitment.
  • Access State: Open Access