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Loehrer, Philipp Alexander [Author]; Schumacher, Wibke [Author]; Krause, Max [Author]; Rizos, Alexandra [Author]; Antonini, Angelo [Author]; Ashkan, Keyoumars [Author]; Martinez-Martin, Pablo [Author]; Gaser, Christian [Author]; Ray Chaudhuri, K. [Author]; Timmermann, Lars [Author]; Baldermann, Juan Carlos [Author]; Dafsari, Haidar S. [Author]; Jost, Stefanie T. [Author]; Silverdale, Monty [Author]; Petry-Schmelzer, Jan Niklas [Author]; Sauerbier, Anna [Author]; Gronostay, Alexandra [Author]; Visser-Vandewalle, Veerle [Author]; Fink, Gereon Rudolf [Author]; Evans, Julian [Author]

No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease

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  • Media type: E-Article
  • Title: No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease
  • Contributor: Loehrer, Philipp Alexander [Author]; Schumacher, Wibke [Author]; Krause, Max [Author]; Rizos, Alexandra [Author]; Antonini, Angelo [Author]; Ashkan, Keyoumars [Author]; Martinez-Martin, Pablo [Author]; Gaser, Christian [Author]; Ray Chaudhuri, K. [Author]; Timmermann, Lars [Author]; Baldermann, Juan Carlos [Author]; Dafsari, Haidar S. [Author]; Jost, Stefanie T. [Author]; Silverdale, Monty [Author]; Petry-Schmelzer, Jan Niklas [Author]; Sauerbier, Anna [Author]; Gronostay, Alexandra [Author]; Visser-Vandewalle, Veerle [Author]; Fink, Gereon Rudolf [Author]; Evans, Julian [Author]
  • Published: Nature Publ. Group, 2024
  • Published in: npj Parkinson's Disease 10(1), 91 (2024). doi:10.1038/s41531-024-00695-1
  • Language: English
  • DOI: https://doi.org/10.1038/s41531-024-00695-1; https://doi.org/10.34734/FZJ-2024-03586
  • ISSN: 2373-8057
  • Origination:
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  • Description: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson's disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for the prediction of non-motor outcomes is limited, we sought to investigate the association between metrics of voxel-based morphometry and short-term non-motor outcomes following STN-DBS in this prospective open-label study. Forty-nine PD patients underwent structural MRI and a comprehensive clinical assessment at preoperative baseline and 6-month follow-up. Voxel-based morphometry was used to assess associations between cerebral volume and non-motor outcomes corrected for multiple comparisons using a permutation-based approach. We replicated existing results associating volume loss of the superior frontal cortex with subpar motor outcomes. Overall non-motor burden, however, was not significantly associated with morphometric features, limiting its use as a marker to inform patient selection and holistic preoperative counselling.
  • Access State: Open Access