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Iida, Hidehiro [Author]; Iguchi, Satoshi [Author]; Kawashima, Hidekazu [Author]; Shah, N. J. [Author]; Nakagawara, Jyoji [Author]; Teramoto, Noboru [Author]; Koshino, Kazuhiro [Author]; Zeniya, Tsutomu [Author]; Yamamoto, Akihide [Author]; Kudomi, Nobuyuki [Author]; Moriguchi, Tetsuaki [Author]; Hori, Yuki [Author]; Enmi, Junichiro [Author]

Adequacy of a compartment model for CMRO$_{2}$ quantitation using $^{15}$O-labeled oxygen and PET: a clearance measurement of $^{15}$O-radioactivity following intracarotid bolus injection of $^{15}$O-labeled oxyhemoglobin on Macaca fascicularis

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  • Media type: E-Article
  • Title: Adequacy of a compartment model for CMRO$_{2}$ quantitation using $^{15}$O-labeled oxygen and PET: a clearance measurement of $^{15}$O-radioactivity following intracarotid bolus injection of $^{15}$O-labeled oxyhemoglobin on Macaca fascicularis
  • Contributor: Iida, Hidehiro [Author]; Iguchi, Satoshi [Author]; Kawashima, Hidekazu [Author]; Shah, N. J. [Author]; Nakagawara, Jyoji [Author]; Teramoto, Noboru [Author]; Koshino, Kazuhiro [Author]; Zeniya, Tsutomu [Author]; Yamamoto, Akihide [Author]; Kudomi, Nobuyuki [Author]; Moriguchi, Tetsuaki [Author]; Hori, Yuki [Author]; Enmi, Junichiro [Author]
  • Published: Ovid, 2014
  • Published in: Journal of cerebral blood flow & metabolism 34, 1434 - 1439 (2014). doi:10.1038/jcbfm.2014.118
  • Language: English
  • DOI: https://doi.org/10.1038/jcbfm.2014.118
  • ISSN: 0271-678X; 1559-7016
  • Origination:
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  • Description: We aimed at evaluating the adequacy of the commonly employed compartmental model for quantitation of cerebral metabolic rate of oxygen (CMRO2) using 15O-labeled oxygen (15O2) and positron emission tomography (PET). Sequential PET imaging was carried out on monkeys following slow bolus injection of blood samples containing 15O2–oxyhemoglobin (15O2–Hb), 15O-labeled water (H215O), and C15O-labeled hemoglobin (C15O–Hb) into the internal carotid artery (ICA). Clearance slopes were assessed in the middle cerebral artery territory of the injected hemisphere. The time–activity curves were bi-exponential for both 15O2–Hb and H215O. Single exponential fitting to the early (5 to 40 seconds) and late (80 to 240 seconds) periods after the peak was performed and the 15O2–Hb and H215O results were compared. It was found that a significant difference between the clearance rates of the 15O2–Hb and H215O injections is unlikely, which supports the mathematical model that is widely used to describe the kinetics of 15O2–Hb and H215O in cerebral tissues and is the basis of recent approaches to simultaneously assess CMRO2 and cerebral blood flow in a single PET session. However, it should be noted that more data are necessary to unequivocally confirm the result.
  • Access State: Open Access