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Kühn, S. [Author]; Musso, F. [Author]; Mobascher, A. [Author]; Warbrick, T. [Author]; Winterer, G. [Author]; Gallinat, J. [Author]

Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry

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  • Media type: E-Article
  • Title: Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry
  • Contributor: Kühn, S. [Author]; Musso, F. [Author]; Mobascher, A. [Author]; Warbrick, T. [Author]; Winterer, G. [Author]; Gallinat, J. [Author]
  • Published: Nature Publishing Group, 2012
  • Published in: Translational Psychiatry 2, e127 (2012). doi:10.1038/tp.2012.51
  • Language: English
  • DOI: https://doi.org/10.1038/tp.2012.51
  • ISSN: 2158-3188
  • Keywords: volumetry ; CA1 ; CA2/3 ; hippocampus ; schizophrenia ; FreeSurfer
  • Origination:
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  • Description: Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields.
  • Access State: Open Access