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Description:
As-72-labelled radiopharmaceuticals could be a valuable resource for Positron Emission Tomography (PET). In particular, the long half-life of As-72 (T-1/2 = 26 h) facilitates the observation of long-term physiological or metabolic processes, such as the enrichment and distribution of antibodies in tumor tissue. This work describes the primary radiochemical separation of no-carrier-added (nca) Se-72 from cyclotron irradiated germanium targets and the development of a polystyrene type solid-phase extraction based Se-72/As-72 radionuclide generator, avoiding the addition of any selenium carrier. The irradiated germanium target is dissolved in HFconc and selenium is reduced with hydrazine dihydrochloride. The nca Se-72((0)) is adsorbed on a solid-phase extraction cartridge, representing the generator column. The As-72 is eluted using various aqueous solvents with 40%-60% yield and < 0.1% Se-72 content. To be able to study the radiopharmaceutical arsenic chemistry, subsequent chemical modification of the nca As-72 eluates to nca [As-72]AsI3 provides a versatile radioarsenic labelling synthon.