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Böhm, Thomas [Author]; Joseph, Kevin [Author]; Haas, Carola A. [Author]; Thiele, Simon [Author]; Kirsch, Matthias [Author]; Moroni, Riko [Author]; Hilger, André [Author]; Osenberg, Markus [Author]; Manke, Ingo [Author]; Johnston, Midori [Author]; Stieglitz, Thomas [Author]; Hofmann, Ulrich G. [Author]

Quantitative synchrotron X-ray tomography of the material-tissue interface in rat cortex implanted with neural probes

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  • Media type: E-Article
  • Title: Quantitative synchrotron X-ray tomography of the material-tissue interface in rat cortex implanted with neural probes
  • Contributor: Böhm, Thomas [Author]; Joseph, Kevin [Author]; Haas, Carola A. [Author]; Thiele, Simon [Author]; Kirsch, Matthias [Author]; Moroni, Riko [Author]; Hilger, André [Author]; Osenberg, Markus [Author]; Manke, Ingo [Author]; Johnston, Midori [Author]; Stieglitz, Thomas [Author]; Hofmann, Ulrich G. [Author]
  • imprint: Macmillan Publishers Limited, part of Springer Nature, 2019
  • Published in: Scientific reports 9(1), 7646 (2019). doi:10.1038/s41598-019-42544-9
  • Language: English
  • DOI: https://doi.org/10.1038/s41598-019-42544-9
  • ISSN: 2045-2322
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: Neural probes provide many options for neuroscientific research and medical purposes. However, these implantable micro devices are not functionally stable over time due to host-probe interactions. Thus, reliable high-resolution characterization methods are required to understand local tissue changes upon implantation. In this work, synchrotron X-ray tomography is employed for the first time to image the interface between brain tissue and an implanted neural probe, showing that this 3D imaging method is capable of resolving probe and surrounding tissue at a resolution of about 1 micrometer. Unstained tissue provides sufficient contrast to identify electrode sites on the probe, cells, and blood vessels within tomograms. Exemplarily, we show that it is possible to quantify characteristics of the interaction region between probe and tissue, like the blood supply system. Our first-time study demonstrates a way for simultaneous 3D investigation of brain tissue with implanted probe, providing information beyond what was hitherto possible.
  • Access State: Open Access