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Vlasov, A. V. [Author]; Kovalev, K. V. [Author]; Ryzhykau, Yu. L. [Author]; Rogachev, A. V. [Author]; Chupin, V. V. [Author]; Kuklin, A. I. [Author]; Dencher, N. A. [Author]; Gordeliy, V. I. [Author]; Marx, S.-H. [Author]; Round, E. S. [Author]; Gushchin, I. Yu. [Author]; Polovinkin, V. A. [Author]; Tsoy, N. M. [Author]; Okhrimenko, I. S. [Author]; Borshchevskiy, V. I. [Author]; Büldt, G. D. [Author]

Unusual features of the c-ring of F1FO ATP synthases

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  • Media type: E-Article
  • Title: Unusual features of the c-ring of F1FO ATP synthases
  • Contributor: Vlasov, A. V. [Author]; Kovalev, K. V. [Author]; Ryzhykau, Yu. L. [Author]; Rogachev, A. V. [Author]; Chupin, V. V. [Author]; Kuklin, A. I. [Author]; Dencher, N. A. [Author]; Gordeliy, V. I. [Author]; Marx, S.-H. [Author]; Round, E. S. [Author]; Gushchin, I. Yu. [Author]; Polovinkin, V. A. [Author]; Tsoy, N. M. [Author]; Okhrimenko, I. S. [Author]; Borshchevskiy, V. I. [Author]; Büldt, G. D. [Author]
  • imprint: Macmillan Publishers Limited, part of Springer Nature, 2019
  • Published in: Scientific reports 9(1), 18547 (2019). doi:10.1038/s41598-019-55092-z
  • Language: English
  • DOI: https://doi.org/10.1038/s41598-019-55092-z
  • ISSN: 2045-2322
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: Membrane integral ATP synthases produce adenosine triphosphate, the universal “energy currency” of most organisms. However, important details of proton driven energy conversion are still unknown. We present the first high-resolution structure (2.3 Å) of the in meso crystallized c-ring of 14 subunits from spinach chloroplasts. The structure reveals molecular mechanisms of intersubunit contacts in the c14-ring, and it shows additional electron densities inside the c-ring which form circles parallel to the membrane plane. Similar densities were found in all known high-resolution structures of c-rings of F1FO ATP synthases from archaea and bacteria to eukaryotes. The densities might originate from isoprenoid quinones (such as coenzyme Q in mitochondria and plastoquinone in chloroplasts) that is consistent with differential UV-Vis spectroscopy of the c-ring samples, unusually large distance between polar/apolar interfaces inside the c-ring and universality among different species. Although additional experiments are required to verify this hypothesis, coenzyme Q and its analogues known as electron carriers of bioenergetic chains may be universal cofactors of ATP synthases, stabilizing c-ring and prevent ion leakage through it.
  • Access State: Open Access