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Shen, Xueyi [Author]; Howard, David M [Author]; McIntosh, Andrew M [Author]; O'Reilly, Paul F [Author]; Oskarsson, Hogni [Author]; Owen, Michael J [Author]; Painter, Jodie N [Author]; Pedersen, Carsten Bøcker [Author]; Pedersen, Marianne Giørtz [Author]; Peterson, Roseann E [Author]; Pettersson, Erik [Author]; Peyrot, Wouter J [Author]; Pistis, Giorgio [Author]; Deary, Ian J [Author]; Posthuma, Danielle [Author]; Quiroz, Jorge A [Author]; Qvist, Per [Author]; Rice, John P [Author]; Riley, Brien P [Author]; Rivera, Margarita [Author]; Mirza, Saira Saeed [Author]; Schoevers, Robert [Author]; Schulte, Eva C [Author]; Shen, Ling [Author]; [...]

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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  • Media type: E-Article
  • Title: A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
  • Contributor: Shen, Xueyi [Author]; Howard, David M [Author]; McIntosh, Andrew M [Author]; O'Reilly, Paul F [Author]; Oskarsson, Hogni [Author]; Owen, Michael J [Author]; Painter, Jodie N [Author]; Pedersen, Carsten Bøcker [Author]; Pedersen, Marianne Giørtz [Author]; Peterson, Roseann E [Author]; Pettersson, Erik [Author]; Peyrot, Wouter J [Author]; Pistis, Giorgio [Author]; Deary, Ian J [Author]; Posthuma, Danielle [Author]; Quiroz, Jorge A [Author]; Qvist, Per [Author]; Rice, John P [Author]; Riley, Brien P [Author]; Rivera, Margarita [Author]; Mirza, Saira Saeed [Author]; Schoevers, Robert [Author]; Schulte, Eva C [Author]; Shen, Ling [Author]; [...]
  • imprint: Nature Publishing Group UK, 2020
  • Published in: Nature Communications 11(1), 2301 (2020). doi:10.1038/s41467-020-16022-0
  • Language: English
  • DOI: https://doi.org/10.1038/s41467-020-16022-0
  • ISSN: 2041-1723
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10-14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.
  • Access State: Open Access