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Kireev, Dmitry [Author]; Qiu, Tianyu [Author]; Wolfrum, Bernhard [Author]; Offenhäusser, Andreas [Author]; Sarik, Dario [Author]; Seyock, Silke [Author]; Wu, Tianru [Author]; Maybeck, Vanessa [Author]; Lottner, Martin [Author]; Blaschke, Benno M [Author]; Garrido, Jose [Author]; Xie, Xiaoming [Author]

From rigid to flexible: graphene-based extracellular sensors

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  • Media type: Electronic Conference Proceeding
  • Title: From rigid to flexible: graphene-based extracellular sensors
  • Contributor: Kireev, Dmitry [Author]; Qiu, Tianyu [Author]; Wolfrum, Bernhard [Author]; Offenhäusser, Andreas [Author]; Sarik, Dario [Author]; Seyock, Silke [Author]; Wu, Tianru [Author]; Maybeck, Vanessa [Author]; Lottner, Martin [Author]; Blaschke, Benno M [Author]; Garrido, Jose [Author]; Xie, Xiaoming [Author]
  • imprint: Forschungszentrum Jülich: JuSER (Juelich Shared Electronic Resources), 2016
  • Published in: Graphene 2016, Genova, Italy, 2016-04-19 - 2016-04-22
  • Language: English
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: Having a chip with a large array of sensitive, fast and linearly responsive, and stable recording sites is a holy grail of biological sensors for the recording of extracellular potentials from electrogenic cells, especially neurons. Such kinds of chips have been and still being fabricated and used. But these chips are mostly based on silicon and silicon technology. The main drawback of these devices is their inflexibility and high Young’s modulus. Therefore, such devices are unusable if one wants to go into flexible in-vivo sensors. Graphene, considering its overall properties [1], seems to be the cornerstone for bringing high tech of microelectronics into flexible shell and into biology. The graphene field effect transistors (GFETs) show great performance in terms of response time (<µs) and linearity (∆VGS into ∆IDS). At the same time, the devices show comprehensively high sensitivity (transconductance over 11 mS/V) and overall stability.In this work we generally compare GFETs fabricated on rigid (silicon and sapphire) and flexible (polyimide) substrates. The devices show truly different performance: silicon shows the worst sensitivity, while sapphire and polyimide have comparably similar great performance, although polyimide is a flexible substrate. We can record extracellular signals with the rigid substrate graphene FETs (Fig. 1) and even calculate their propagation through the chip (Fig. 2). We can even record the “reaction” of the cellular layer on special drugs and chemicals: addition of 20 μL of NorA into the cell culture medium doubles their beating frequency, while addition of a surfactant (SDS) results in a slow dissolving of the cellular layer and therefore disappearance of the beating (Fig. 2c). But is this a huge step forward? This had been done years ago with silicon FETs [2] and multi electrode arrays (MEAs) [3].In order to go further we have fabricated similar GFETs on flexible polyimide (PI) substrate (Fig. 3a). These devices, while difficult to perform the usual in-vitro tests, due to ...
  • Access State: Open Access