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Kleineberg, Nina N. [Author]; Knauss, Samuel [Author]; Endres, Matthias [Author]; Gerloff, Christian [Author]; Klein, Christine [Author]; Stecher, Melanie [Author]; Classen, Annika Y. [Author]; Rieg, Siegbert [Author]; Borgmann, Stefan [Author]; Hanses, Frank [Author]; Rüthrich, Maria M. [Author]; Hower, Martin [Author]; Gülke, Eileen [Author]; Tometten, Lukas [Author]; Haselberger, Martina [Author]; Piepel, Christiane [Author]; Merle, Uta [Author]; Dolff, Sebastian [Author]; Degenhardt, Christian [Author]; Jensen, Björn-Erik O. [Author]; Vehreschild, Maria J. G. T. [Author]; Erber, Johanna [Author]; Franke, Christiana [Author]; Pinnschmidt, Hans O. [Author]; [...]

Neurological symptoms and complications in predominantly hospitalized COVID‐19 patients: Results of the European multinational Lean European Open Survey on SARS‐Infected Patients (LEOSS)

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  • Media type: E-Article
  • Title: Neurological symptoms and complications in predominantly hospitalized COVID‐19 patients: Results of the European multinational Lean European Open Survey on SARS‐Infected Patients (LEOSS)
  • Contributor: Kleineberg, Nina N. [Author]; Knauss, Samuel [Author]; Endres, Matthias [Author]; Gerloff, Christian [Author]; Klein, Christine [Author]; Stecher, Melanie [Author]; Classen, Annika Y. [Author]; Rieg, Siegbert [Author]; Borgmann, Stefan [Author]; Hanses, Frank [Author]; Rüthrich, Maria M. [Author]; Hower, Martin [Author]; Gülke, Eileen [Author]; Tometten, Lukas [Author]; Haselberger, Martina [Author]; Piepel, Christiane [Author]; Merle, Uta [Author]; Dolff, Sebastian [Author]; Degenhardt, Christian [Author]; Jensen, Björn-Erik O. [Author]; Vehreschild, Maria J. G. T. [Author]; Erber, Johanna [Author]; Franke, Christiana [Author]; Pinnschmidt, Hans O. [Author]; [...]
  • imprint: Blackwell Science, 2021
  • Published in: European journal of neurology 28(12), 3925-3937 (2021). doi:10.1111/ene.15072
  • Language: English
  • DOI: https://doi.org/10.1111/ene.15072
  • ISSN: 1468-1331; 1351-5101; 1471-0552
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: Background and purposeDuring acute coronavirus disease 2019 (COVID-19) infection, neurological signs, symptoms and complications occur. We aimed to assess their clinical relevance by evaluating real-world data from a multinational registry.MethodsWe analyzed COVID-19 patients from 127 centers, diagnosed between January 2020 and February 2021, and registered in the European multinational LEOSS (Lean European Open Survey on SARS-Infected Patients) registry. The effects of prior neurological diseases and the effect of neurological symptoms on outcome were studied using multivariate logistic regression.ResultsA total of 6537 COVID-19 patients (97.7% PCR-confirmed) were analyzed, of whom 92.1% were hospitalized and 14.7% died. Commonly, excessive tiredness (28.0%), headache (18.5%), nausea/emesis (16.6%), muscular weakness (17.0%), impaired sense of smell (9.0%) and taste (12.8%), and delirium (6.7%) were reported. In patients with a complicated or critical disease course (53%) the most frequent neurological complications were ischemic stroke (1.0%) and intracerebral bleeding (ICB; 2.2%). ICB peaked in the critical disease phase (5%) and was associated with the administration of anticoagulation and extracorporeal membrane oxygenation (ECMO). Excessive tiredness (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.20–1.68) and prior neurodegenerative diseases (OR 1.32, 95% CI 1.07–1.63) were associated with an increased risk of an unfavorable outcome. Prior cerebrovascular and neuroimmunological diseases were not associated with an unfavorable short-term outcome of COVID-19.ConclusionOur data on mostly hospitalized COVID-19 patients show that excessive tiredness or prior neurodegenerative disease at first presentation increase the risk of an unfavorable short-term outcome. ICB in critical COVID-19 was associated with therapeutic interventions, such as anticoagulation and ECMO, and thus may be an indirect complication of a life-threatening systemic viral infection.
  • Access State: Open Access