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Jost, Stefanie T. [Author]; Ray Chaudhuri, K. [Author]; Fink, Gereon R. [Author]; Visser-Vandewalle, Veerle [Author]; Antonini, Angelo [Author]; Martinez-Martin, Pablo [Author]; Timmermann, Lars [Author]; Dafsari, Haidar S. [Author]; Ashkan, Keyoumars [Author]; Loehrer, Philipp A. [Author]; Silverdale, Monty [Author]; Rizos, Alexandra [Author]; Evans, Julian [Author]; Petry-Schmelzer, Jan Niklas [Author]; Barbe, Michael T. [Author]; Sauerbier, Anna [Author]

Subthalamic Stimulation Improves Quality of Sleep in Parkinson Disease: A 36-Month Controlled Study

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  • Media type: E-Article
  • Title: Subthalamic Stimulation Improves Quality of Sleep in Parkinson Disease: A 36-Month Controlled Study
  • Contributor: Jost, Stefanie T. [Author]; Ray Chaudhuri, K. [Author]; Fink, Gereon R. [Author]; Visser-Vandewalle, Veerle [Author]; Antonini, Angelo [Author]; Martinez-Martin, Pablo [Author]; Timmermann, Lars [Author]; Dafsari, Haidar S. [Author]; Ashkan, Keyoumars [Author]; Loehrer, Philipp A. [Author]; Silverdale, Monty [Author]; Rizos, Alexandra [Author]; Evans, Julian [Author]; Petry-Schmelzer, Jan Niklas [Author]; Barbe, Michael T. [Author]; Sauerbier, Anna [Author]
  • imprint: IOS Press, 2021
  • Published in: Journal of Parkinson's Disease 11(1), 323 - 335 (2021). doi:10.3233/JPD-202278
  • Language: English
  • DOI: https://doi.org/10.3233/JPD-202278
  • ISSN: 1877-718X; 1877-7171
  • Origination:
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  • Description: Background:Sleep disturbances and neuropsychiatric symptoms are some of the most common nonmotor symptoms in Parkinson’s disease (PD). The effect of subthalamic stimulation (STN-DBS) on these symptoms beyond a short-term follow-up is unclear.Objective:To examine 36-month effects of bilateral STN-DBS on quality of sleep, depression, anxiety, and quality of life (QoL) compared to standard-of-care medical therapy (MED) in PD.Methods:In this prospective, controlled, observational, propensity score matched, international multicenter study, we assessed sleep disturbances using the PDSleep Scale-1 (PDSS), QoL employing the PDQuestionnaire-8 (PDQ-8), motor disorder with the Scales for Outcomes in PD (SCOPA), anxiety and depression with the Hospital Anxiety and Depression Scale (HADS), and dopaminergic medication requirements (LEDD). Within-group longitudinal outcome changes were tested using Wilcoxon signed-rank and between-group longitudinal differences of change scores with Mann-Whitney U tests. Spearman correlations analyzed the relationships of outcome parameter changes at follow-up.Results:Propensity score matching applied on 159 patients (STN-DBS n = 75, MED n = 84) resulted in 40 patients in each treatment group. At 36-month follow-up, STN-DBS led to significantly better PDSS and PDQ-8 change scores, which were significantly correlated. We observed no significant effects for HADS and no significant correlations between change scores in PDSS, HADS, and LEDD.Conclusions:We report Class IIb evidence of beneficial effects of STN-DBS on quality of sleep at 36-month follow-up, which were associated with QoL improvement independent of depression and dopaminergic medication. Our study highlights the importance of sleep for assessments of DBS outcomes.
  • Access State: Open Access