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Davison, Angus [Author]; McDowell, Gary S. [Author]; Holden, Jennifer M. [Author]; Johnson, Harriet F. [Author]; Koutsovoulos, Georgios D. [Author]; Liu, M. Maureen [Author]; Hulpiau, Paco [Author]; Van Roy, Frans [Author]; Wade, Christopher M. [Author]; Banerjee, Ruby [Author]; Yang, Fengtang [Author]; Chiba, Satoshi [Author]; Davey, John W. [Author]; Jackson, Daniel J. [Author]; Levin, Michael [Author]; Blaxter, Mark L. [Author]

Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog

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  • Media type: E-Article
  • Title: Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog
  • Contributor: Davison, Angus [Author]; McDowell, Gary S. [Author]; Holden, Jennifer M. [Author]; Johnson, Harriet F. [Author]; Koutsovoulos, Georgios D. [Author]; Liu, M. Maureen [Author]; Hulpiau, Paco [Author]; Van Roy, Frans [Author]; Wade, Christopher M. [Author]; Banerjee, Ruby [Author]; Yang, Fengtang [Author]; Chiba, Satoshi [Author]; Davey, John W. [Author]; Jackson, Daniel J. [Author]; Levin, Michael [Author]; Blaxter, Mark L. [Author]
  • imprint: GEO-LEOe-docs (FID GEO), 2016
  • Language: English
  • DOI: https://doi.org/10.1016/j.cub.2015.12.071
  • ISSN: 1879-0445
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: While components of the pathway that establishes left-right asymmetry have been identified in diverse animals, from vertebrates to flies, it is striking that the genes involved in the first symmetry-breaking step remain wholly unknown in the most obviously chiral animals, the gastropod snails. Previously, research on snails was used to show that left-right signaling of Nodal, downstream of symmetry breaking, may be an ancestral feature of the Bilateria [1, 2]. Here, we report that a disabling mutation in one copy of a tandemly duplicated, diaphanousrelated formin is perfectly associated with symmetry breaking in the pond snail. This is supported by the observation that an anti-formin drug treatment converts dextral snail embryos to a sinistral phenocopy, and in frogs, drug inhibition or overexpression by microinjection of formin has a chirality-randomizing effect in early (pre-cilia) embryos. Contrary to expectations based on existingmodels [3–5],wediscovered asymmetric gene expression in 2- and 4-cell snail embryos, preceding morphological asymmetry. As the formin-actin filament has been shown to be part of an asymmetry-breaking switch in vitro [6, 7], together these results are consistent with the view that animals with diverse body plans may derive their asymmetries from the same intracellular chiral elements [8].
  • Access State: Open Access
  • Rights information: Attribution (CC BY)