In-vitro-Vergleich der gerinnungshemmenden Wirkung von Danaparoid, unfraktioniertem und niedermolekularem Heparin im Herzkatheter- und Herzklappenthrombose-Modell

Media type: E-Book

Title: In-vitro-Vergleich der gerinnungshemmenden Wirkung von Danaparoid, unfraktioniertem und niedermolekularem Heparin im Herzkatheter- und Herzklappenthrombose-Modell

Contributor: Horenburg, Charlotte [Author]; Schlitt, Axel [Other]; Szabó, Gábor [Other]; Weiß, Christian [Other]

Published: Halle (Saale): Universitäts- und Landesbibliothek Sachsen-Anhalt, 2022

Extent: Online-Ressource

Language: German

DOI: 10.25673/86289

Identifier:

Keywords: Koronare Herzkrankheit ; Pharmakotherapie ; Antikoagulans ; Sekundärkrankheit ; Künstliche Herzklappe ; Intensivtherapie ; Patients who develop heparin-induced thrombocytopenia (HIT) while receiving unfractionated heparin (UFH) need another anticoagulation ; especially when requiring percutaneous coronary intervention or having a mechanical heart valve in situ. This study compares the anticoagulant effect of danaparoid ; UFH and enoxaparin on preventing thrombus formation at mechanical heart valves and in cardiac catheters by using two in-vitro systems. Danaparoid was superior to UFH and enoxaparin in preventing thrombus formation at mechanical heart valves as thrombus weight was lowest in the danaparoid group ; whereas thrombus formation in cardiac catheters was increased using danaparoid as compared to UFH und enoxaparin. These results suggest that danaparoid is not as effective as UFH and enoxaparin in preventing cardiac catheter thrombosis while it seems to be a potent alternative to UFH in patients with mechanical heart valve replacement and HIT ; which is worth further studies. ; Danaparoid ; Heparin-induzierte Thrombozytopenie ; Katheterthrombose ; mechanische Herzklappe ; perkutane Koronarintervention ; Antikoagulation ; Enoxaparin ; danaparoid ; heparin-induced thrombocytopenia ; mechanical heart valve ; percutaneous coronary intervention ; cardiac catheter thrombosis ; enoxaparin ;

Origination:

University thesis: Dissertation, Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, 2022

Footnote:

Access State: Open Access

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