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Safar, Michel [Other]

Atherosclerosis, large arteries and cardiovascular risk

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  • Media type: E-Book
  • Title: Atherosclerosis, large arteries and cardiovascular risk : new perspectives for the prevention and treatment of cardiovascular events
  • Contains: ""Cover""; ""Contents""; ""Preface""; ""Section I â€? Pathophysiology""; ""Arterial Stiffness:A Simplified Overview in Vascular Medicine""; ""Abstract""; ""Blood Pressure and the Mechanical Behavior of the Arterial Wall""; ""Cardiac Contraction and Aortic Consequences of Intermittent Ventricular Ejection""; ""BP Propagation and Amplification""; ""Transition from the Macro-to the Microcirculation""; ""Pulse Wave Morphology and Analysis""; ""Wave Ref lection,Arterial Stiffness and Ventricular Load""; ""Vessel Wall and Mechanical Properties of Conduit Arteries""
    ""Mechanical Stress and Arterial Remodeling""""Pathophysiological Changes of Arterial Stiffness and Wave Reflections""; ""Arterial Stiffness, Aging, Arteriosclerosis and Atherosclerosis""; ""Aging, Loss of Elastin and Fatigue""; ""Atherosclerosis versus Arteriosclerosis""; ""Acknowledgments""; ""References""; ""Aging and Arterial Structure-Function Relations""; ""Abstract""; ""Aging and Blood Pressure""; ""BP Components and Risk""; ""Arterial Wall Structure-Function Relations""; ""Arterial Changes in Aging and Hypertension""; ""Wide Pulse Pressure:Stiffness vs.Diameter""
    ""Pulse Transmission in Conduit Arteries""""Amplification and Reflection:Central vs.Peripheral BP""; ""Small Arteries and Arterioles""; ""References""; ""Local Elasticity Imaging of Vulnerable Atherosclerotic Coronary Plaques""; ""Abstract""; ""1.Vulnerable Plaque:Description and Pathophysiology""; ""Introduction""; ""Conceptual Terms""; ""Overview""; ""The Vulnerable Patient""; ""Vulnerable/High-Risk/Thrombosis-Prone Plaques""; ""Histologic Features of Plaques Causing Coronary Artery Thrombosis""; ""Prospective Identification of a Vulnerable Plaque""; ""A Plaque Prone to Erosion""
    ""A Plaque with a Calcified Nodule""""Novel Imaging Techniques Will Provide Additional Information on Vulnerable Plaques""; ""2.Vulnerable Plaque:Elasticity Imaging""; ""Introduction""; ""Elasticity Imaging""; ""The Movement Begins""; ""IVUS Strain Elastography/Palpography""; ""Implementation of the Technique""; ""IVUS Strain Elastography/Palpography:Results""; ""In vitro Validation on Human Arteries""; ""In vivo Animal Studies""; ""In vivo Patient Studies""; ""Ultrasound Modulus Elastography""; ""Motivation""; ""Implementation of the Technique""; ""IVUS Modulus Elastography""
    ""IVUS Modulus Elastography of Vulnerable Plaques:Results""""IVUS Modulus Elastography of Arbitrary Atherosclerotic Plaques""; ""Discussion and Conclusion""; ""Acknowledgements""; ""References""; ""Endothelial Function,Mechanical Stress and Atherosclerosis""; ""Abstract""; ""Normal Endothelial Function""; ""Endothelial Function and Atherosclerosis""; ""Mechanical Stress and Endothelial Function""; ""Nitric Oxide and Age-Related Changes in Stiffness""; ""References""; ""Arterial Stiffness and Extracellular Matrix""; ""Abstract""; ""Introduction""; ""Vascular Collagen""
    ""Synthesis and Secretion""
  • Contributor: Safar, Michel [Other]
  • Published: Basel; New York: Karger, 2007
    Online-Ausg.
  • Published in: Advances in cardiology ; 44
  • Extent: Online-Ressource (VIII, 360 S.)
  • Language: English
  • DOI: 10.1159/isbn.978-3-318-01395-5
  • ISBN: 9783318013955; 1429468408; 9781429468404
  • Identifier:
  • RVK notation: YC 1100 : Allgemeines
  • Keywords: Arteriosclerosis Pathophysiology ; Coronary heart disease Etiology ; Atherosclerosis Pathophysiology ; Atherosclerosis physiopathology ; Arteries physiopathology ; Atherosclerosis complications ; Cardiovascular Diseases etiology ; Risk Factors ; Cardiovascular System ; Diabetes ; Gerontology / Geriatrics ; Nephrology ; Pharmacology
  • Reproduction series: Karger eBooks Collection 1997-2009
  • Type of reproduction: Online-Ausg.
  • Origination:
  • Footnote: Includes bibliographical references and indexes
  • Description: Arterial stiffness is now firmly established as an important and independent predictor of cardiovascular risk. The structural and functional changes of the large arteries may be age-related, but a number of conditions have been associated with accelerated arterial stiffening including the hypertensive diseases, atherosclerosis, end-stage renal disease, and traditional cardiovascular risk factors such as diabetes mellitus and smoking.This book presents the current thinking of international experts regarding the underlying mechanisms of cardiovascular risk, and the pathogenesis and pathophysiology of large arterial stiffness and reduced large arterial distensibility. It not only gives new insights into the relationship between arterial stiffness and atherosclerosis, but also establishes the possible interactions with age and other cardiovascular factors such as high blood pressure, diabetes and hyperlipidemia. Finally, the therapeutic means of approaching arterial stiffness are analyzed in detail and new perspectives for the treatment and prevention of cardiovascular diseases are developed.Authoritative and up-to-date, this book is a valuable resource for basic scientists interested in vascular physiology and pathophysiology, for clinicians in the areas of cardiology, diabetes and renal diseases, as well as for investigators in drug development