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Löffler, Dennis [Author]; Brocke-Heidrich, Katja [Author]; Pfeifer, Gabriele [Author]; Stocsits, Claudia [Author]; Hackermüller, Jörg [Author]; Kretzschmar, Antje K. [Author]; Burger, Renate [Author]; Gramatzki, Martin [Author]; Blumert, Conny [Author]; Bauer, Kay [Author]; Cvijic, Helena [Author]; Ullmann, Kerstin [Author]; Stadler, Peter F. [Author]; Horn, Friedemann [Author]

Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of micro-RNA-21 through a highly conserved enhancer

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  • Media type: E-Article
  • Title: Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of micro-RNA-21 through a highly conserved enhancer
  • Contributor: Löffler, Dennis [Author]; Brocke-Heidrich, Katja [Author]; Pfeifer, Gabriele [Author]; Stocsits, Claudia [Author]; Hackermüller, Jörg [Author]; Kretzschmar, Antje K. [Author]; Burger, Renate [Author]; Gramatzki, Martin [Author]; Blumert, Conny [Author]; Bauer, Kay [Author]; Cvijic, Helena [Author]; Ullmann, Kerstin [Author]; Stadler, Peter F. [Author]; Horn, Friedemann [Author]
  • imprint: [2018]
  • Language: English
  • ISSN: 0006-4971
  • Keywords: Evolutionary biology ; RNA ; Biochemistry
  • Origination:
  • Footnote:
  • Description: Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6–dependent survival and growth of multiple myeloma cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is controlled by an upstream enhancer containing 2 Stat3 binding sites strictly conserved since the first observed evolutionary appearance of miR-21 and Stat3. MiR-21 induction by IL-6 was strictly Stat3 dependent. Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3.
  • Access State: Open Access