Footnote:
Hinweis: Link zur Erstveröffentlichung URL: https://dx.doi.org/10.1177/0284185120927905
Description:
Background: Despite the high sensitivity of magnetic resonance imaging (MRI), early detection of spondylodiscitis
(SpD) remains challenging due to its low specificity.
Purpose: To assess the diagnostic value of diffusion-weighted imaging (DWI) in suspected cases of SpD with ambiguous
early MRI findings in the differentiation of degenerative disorders (DD).
Material and Methods: In this prospective study, 52 patients suspected of having SpD underwent a whole-spine 3-T
MRI scan comprising sagittal DWI. Of 58 conspicuous, T2-weighted, signal increased discs, 39 were successfully evaluated
using DWI. Apparent diffusion coefficient (ADC) values and ADC maps were blindly analyzed using the region of
interest of the conspicuous disc and a normal adjacent reference disc. Intraindividual ratios (conspicuous disc: reference
disc) were calculated.
Results: All conspicuous discs showed increased absolute ADC values, which did not differ significantly between SpD
(n¼22) and DD (n¼17). However, ADC ratio was significantly higher in SpD vs. DD (P<0.05). In receiver operating
characteristic curve analysis, an ADC ratio threshold of 1.6 resulted in 45% sensitivity and 88% specificity (area under
the curve¼0.69) for SpD diagnosis.
Conclusion: The absolute ADC value does not provide a reliable diagnosis of SpD. Increased diffusivity can be an
indication of infection but should always be discussed in the context of existing disc degeneration.