Hoppenrath, Kathrin
[Author];
Härtig, Wolfgang
[Author];
Funke, Klaus
[Author]
Intermittent Theta-Burst Transcranial Magnetic Stimulation Alters Electrical Properties of Fast-Spiking Neocortical Interneurons in an Age-Dependent Fashion
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Media type:
E-Article
Title:
Intermittent Theta-Burst Transcranial Magnetic Stimulation Alters Electrical Properties of Fast-Spiking Neocortical Interneurons in an Age-Dependent Fashion
Contributor:
Hoppenrath, Kathrin
[Author];
Härtig, Wolfgang
[Author];
Funke, Klaus
[Author]
imprint:
Lausanne: Frontiers Media, [2023]
Published in:Frontiers in Neural Circuits ; 10 (2016), Seite 1-13
Description:
Modulation of human cortical excitability by repetitive transcranial magnetic stimulation(rTMS) appears to be in part related to changed activity of inhibitory systems. Ourown studies showed that intermittent theta-burst stimulation (iTBS) applied via rTMSto rat cortex primarily affects the parvalbumin-expressing (PV) fast-spiking interneurons(FSIs), evident via a strongly reduced PV expression. We further found the iTBSeffect on PV to be age-dependent since no reduction in PV could be inducedbefore the perineuronal nets (PNNs) of FSIs start to grow around postnatal day(PD) 30. To elucidate possible iTBS-induced changes in the electrical propertiesof FSIs and cortical network activity during cortical critical period, we performedex vivo—in vitro whole-cell patch clamp recordings from pre-labeled FSIs in thecurrent study. FSIs of verum iTBS-treated rats displayed a higher excitability thansham-treated controls at PD29–38, evident as higher rates of induced actionpotential firing at low current injections (100–200 pA) and a more depolarizedresting membrane potential. This effect was absent in younger (PD26–28) and olderanimals (PD40–62). Slices of verum iTBS-treated rats further showed higher ratesof spontaneous excitatory postsynaptic currents (sEPSCs). Based on these andprevious findings we conclude that FSIs are particularly sensitive to TBS duringearly cortical development, when FSIs show an activity-driven step of maturationwhich is paralleled by intense growth of the PNNs and subsequent closure of thecortical critical period. Although to be proven further, rTMS may be a possibleearly intervention to compensate for hypo-activity related mal-development of corticalneuronal circuits.