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Strzelczyk, Alexander Klaus [Author]; Wang, Hanqing [Author]; Lindhorst, Andreas [Author]; Waschke, Johannes [Author]; Pompe, Tilo [Author]; Kropf, Christian [Author]; Luneau, Benoit [Author]; Schmidt, Stephan [Author]

Hydrogel Microparticles as Sensors for Specific Adhesion: Case Studies on Antibody Detection and Soil Release Polymers

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  • Media type: E-Article
  • Title: Hydrogel Microparticles as Sensors for Specific Adhesion: Case Studies on Antibody Detection and Soil Release Polymers
  • Contributor: Strzelczyk, Alexander Klaus [Author]; Wang, Hanqing [Author]; Lindhorst, Andreas [Author]; Waschke, Johannes [Author]; Pompe, Tilo [Author]; Kropf, Christian [Author]; Luneau, Benoit [Author]; Schmidt, Stephan [Author]
  • imprint: Basel: MDPI, [2023]
  • Published in: Gels ; 3,3, (2017)
  • Language: English
  • Keywords: biomimetic hydrogel ; contact mechanics ; soft colloidal probe ; biointerface ; reflection interference contrast microscopy (RICM) ; poly(ethylene glycol) (PEG) ; elastic solids
  • Origination:
  • Footnote:
  • Description: Adhesive processes in aqueous media play a crucial role in nature and are important formany technological processes. However, direct quantification of adhesion still requires expensiveinstrumentation while their sample throughput is rather small. Here we present a fast, andeasily applicable method on quantifying adhesion energy in water based on interferometricmeasurement of polymer microgel contact areas with functionalized glass slides and evaluation viathe Johnson–Kendall–Roberts (JKR) model. The advantage of the method is that the microgel matrixcan be easily adapted to reconstruct various biological or technological adhesion processes. Here westudy the suitability of the new adhesion method with two relevant examples: (1) antibody detectionand (2) soil release polymers. The measurement of adhesion energy provides direct insights on thepresence of antibodies showing that the method can be generally used for biomolecule detection. As arelevant example of adhesion in technology, the antiadhesive properties of soil release polymers usedin today’s laundry products are investigated. Here the measurement of adhesion energy providesdirect insights into the relation between polymer composition and soil release activity. Overall, thework shows that polymer hydrogel particles can be used as versatile adhesion sensors to investigatea broad range of adhesion processes in aqueous media.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)