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Fiedler, Lukas [Author]; Hallsson, Lára [Author]; Tscharre, Maximilian [Author]; Oebel, Sabrina [Author]; Pfeffer, Michael [Author]; Schönbauer, Robert [Author]; Tokarska, Lyudmyla [Author]; Stix, Laura [Author]; Haiden, Anton [Author]; Kraus, Johannes [Author]; Blessberger, Hermann [Author]; Siebert, Uwe [Author]; Roithinger, Franz Xaver [Author]

Upstream Statin Therapy and Long-Term Recurrence of Atrial Fibrillation after Cardioversion: A Propensity-Matched Analysis

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  • Media type: E-Article
  • Title: Upstream Statin Therapy and Long-Term Recurrence of Atrial Fibrillation after Cardioversion: A Propensity-Matched Analysis
  • Contributor: Fiedler, Lukas [Author]; Hallsson, Lára [Author]; Tscharre, Maximilian [Author]; Oebel, Sabrina [Author]; Pfeffer, Michael [Author]; Schönbauer, Robert [Author]; Tokarska, Lyudmyla [Author]; Stix, Laura [Author]; Haiden, Anton [Author]; Kraus, Johannes [Author]; Blessberger, Hermann [Author]; Siebert, Uwe [Author]; Roithinger, Franz Xaver [Author]
  • imprint: Basel : MDPI, [2023]
  • Language: English
  • Keywords: statin; atrial fibrillation; cardioversion; recurrence ; Medizin ; medicine
  • Origination:
  • Footnote: Hinweis: Link zur Erstveröffentlichung URL: https://doi.org/10.3390/jcm10040807
  • Description: The relationship of statin therapy with recurrence of atrial fibrillation (AF) after cardioversion (CV) has been evaluated by several investigations, which provided conflicting results and particularly long-term data is scarce. We sought to examine whether upstream statin therapy is associated with long-term recurrence of AF after CV. This was a single-center registry study including consecutive AF patients (n = 454) undergoing CV. Cox regression models were performed to estimate AF recurrence comparing patients with and without statins. In addition, we performed a propensity score matched analysis with a 1:1 ratio. Statins were prescribed to 183 (40.3%) patients. After a median follow-up period of 373 (207–805) days, recurrence of AF was present in 150 (33.0%) patients. Patients receiving statins had a significantly lower rate of AF recurrence (log-rank p < 0.001). In univariate analysis, statin therapy was associated with a significantly reduced rate of AF recurrence (HR 0.333 (95% CI 0.225–0.493), p = 0.001), which remained significant after adjustment (HR 0.238 (95% CI 0.151–0.375), p < 0.001). After propensity score matching treatment with statins resulted in an absolute risk reduction of 27.5% for recurrent AF (21 (18.1%) vs. 53 (45.7%); p < 0.001). Statin therapy was associated with a reduced risk of long-term AF recurrence after successful cardioversion.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)