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Fodor, Margot [Author]; Lanser, Lukas [Author]; Hofmann, Julia [Author]; Otarashvili, Giorgi [Author]; Pühringer, Marlene [Author]; Cardini, Benno [Author]; Oberhuber, Rubert [Author]; Resch, Thomas [Author]; Weissenbacher, Annemarie [Author]; Maglione, Manuel [Author]; Margreiter, Christian [Author]; Zelger, Philipp [Author]; Pallua, Johannes D. [Author]; Öfner, Dietmar [Author]; Sucher, Robert [Author]; Hautz, Theresa [Author]; Schneeberger, Stefan [Author]

Hyperspectral Imaging as a Tool for Viability Assessment During Normothermic Machine Perfusion of Human Livers: A Proof of Concept Pilot Study

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  • Media type: E-Article
  • Title: Hyperspectral Imaging as a Tool for Viability Assessment During Normothermic Machine Perfusion of Human Livers: A Proof of Concept Pilot Study
  • Contributor: Fodor, Margot [Author]; Lanser, Lukas [Author]; Hofmann, Julia [Author]; Otarashvili, Giorgi [Author]; Pühringer, Marlene [Author]; Cardini, Benno [Author]; Oberhuber, Rubert [Author]; Resch, Thomas [Author]; Weissenbacher, Annemarie [Author]; Maglione, Manuel [Author]; Margreiter, Christian [Author]; Zelger, Philipp [Author]; Pallua, Johannes D. [Author]; Öfner, Dietmar [Author]; Sucher, Robert [Author]; Hautz, Theresa [Author]; Schneeberger, Stefan [Author]
  • imprint: Lausanne: Frontiers Media, [2023]
  • Published in: Transplant international ; 35, (2022)
  • Language: English
  • Keywords: machine ; perfusion ; hyperspectral ; imaging ; transplantation ; normothermic ; liver
  • Origination:
  • Footnote:
  • Description: Normothermic machine perfusion (NMP) allows for ex vivo viability and functionalassessment prior to liver transplantation (LT). Hyperspectral imaging represents asuitable, non-invasive method to evaluate tissue morphology and organ perfusionduring NMP. Liver allografts were subjected to NMP prior to LT. Serial imageacquisition of oxygen saturation levels (StO2), organ hemoglobin (THI), near-infraredperfusion (NIR) and tissue water indices (TWI) through hyperspectral imaging wasperformed during static cold storage, at 1h, 6h, 12h and at the end of NMP. Thereadouts were correlated with perfusate parameters at equivalent time points. Twentyonedeceased donor livers were included in the study. Seven (33.0%) were discarded dueto poor organ function during NMP. StO2 (p < 0.001), THI (p < 0.001) and NIR (p = 0.002)significantly augmented, from static cold storage (pre-NMP) to NMP end, while TWIdropped (p = 0.005) during the observational period. At 12–24h, a significantly higherhemoglobin concentration (THI) in the superficial tissue layers was seen in discarded,compared to transplanted livers (p = 0.036). Lactate values at 12h NMP correlatednegatively with NIR perfusion index between 12 and 24h NMP and with the delta NIRperfusion index between 1 and 24h (rs = −0.883, p = 0.008 for both). Furthermore, NIR andTWI correlated with lactate clearance and pH. This study provides first evidence of feasibility of hyperspectral imaging as a potentially helpful contact-free organ viabilityassessment tool during liver NMP.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)