Description:
Background: Dyslipidemia is strongly associated with the development of hypertension.In our previous study, it was shown that elevated TC, LDL-c, and non-HDL-c wereassociated with the prevalence of hypertension in Chinese men, whereas the relationshipbetween HDL-c and hypertension shifted from no association to a positive associationafter adjusting for the BMI. To further accumulate epidemiological evidence in Asianwomen, this study aimed to investigate the relationship between lipid profile andprevalence of hypertension in Chinese adult women.Methods: This is a cross-sectional study including 54,099 Chinese women aged>20years at 32 health screening centers in 11 cities from 2010-2016. The original data wereobtained from DATADRYAD database (www.datadryad.org). Besides, the overall womenwere classified into non-hypertensive and hypertensive groups based on baseline bloodpressure levels. Differences between the two groups were examined by Man-Whitney testor Chi-square test. Spearman’s correlation coefficient was employed to evaluate thecorrelation between systolic blood pressure (SBP), diastolic blood pressure (DBP) andlipid profiles. Multivariate logistic regression was performed to estimate the relationshipbetween different lipid levels and the prevalence of hypertension. Odds ratios (ORs) and95% confidence intervals (CIs) indicated the risk of lipid and hypertension. Bayesian model(BN) model was constructed to further assess the relationship between baselinecharacteristics and the prevalence of hypertension, as well as the importance of eachvariable for the prevalence of hypertension.Results: Compared to the non-hypertensive population, the hypertensive population wasolder, and had the higher body mass index (BMI), total cholesterol (TC), low-densitylipoprotein cholesterol (LDL-c), serum creatinine (Scr), fasting blood glucose (FPG), bloodurea nitrogen (BUN), alanine aminotransferase (ALT), aspartate aminotransferase (AST),and non-high-density lipoprotein cholesterol (non-HDL-c), but HDL-c and the presenceconcerning the family history of diabetes were lower. Multivariate logistic regressionanalysis revealed that TC, LDL-c, and non-HDL-c showed a positive trend with hypertension risk (p for trend < 0.05) whereas TC and HDL-c were not significantly associatedwith hypertension prevalence. Moreover, each 1 mg/dl increase in TC, LDL, and non-HDLhypertension prevalence increased by 0.2% [1.002 (1.000-1.003)], 0.2% [1.002 (1.000-1.004)], and 0.2% [1.002(1.001-1.004)], respectively. BN suggested that the importance ofage, BMI, FPG, non-HDL-c on the prevalence of hypertension was 52.73%, 24.98%, 11.22%,and 2.34%, respectively.Conclusion: Overall, in Chinese adult women, TC, LDL-c and non-HDL-c levels were higherand HDL-c level was lower in the hypertensive population, whereas TG did not differsignificantly from the non-hypertensive population. Meanwhile, TC, LDL-c, and non-HDL-cwere positively associated with prevalence of hypertension, and HDL-c was negativelyassociated with prevalence of hypertension but became nonsignificant after full adjustmentfor variables. Moreover, BN model suggested that age, BMI, FPG, and non-HDL-c had agreater effect on the development of hypertension.