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Beinhölzl, Nathalie [Author]; Molloy, Eóin N. [Author]; Zsido, Rachel G. [Author]; Richter, Thalia [Author]; Piecha, Fabian A. [Author]; Zheleva, Gergana [Author]; Scharrer, Ulrike [Author]; Regenthal, Ralf [Author]; Villringer, Arno [Author]; Okon-Singer, Hadas [Author]; Sacher, Julia [Author]

The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake

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  • Media type: E-Article
  • Title: The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake
  • Contributor: Beinhölzl, Nathalie [Author]; Molloy, Eóin N. [Author]; Zsido, Rachel G. [Author]; Richter, Thalia [Author]; Piecha, Fabian A. [Author]; Zheleva, Gergana [Author]; Scharrer, Ulrike [Author]; Regenthal, Ralf [Author]; Villringer, Arno [Author]; Okon-Singer, Hadas [Author]; Sacher, Julia [Author]
  • Published: Lausanne: Frontiers Media S.A., [2023]
  • Published in: Frontiers in neuroscience ; 16 (2022), Seite 1-13
  • Language: English
  • DOI: 10.3389/fnins.2022.809269
  • Keywords: emotional flanker task ; female mental health ; selective serotonin reuptake inhibitors ; oral hormonal contraceptives ; attention-emotion interaction
  • Origination:
  • Footnote:
  • Description: Previous findings in healthy humans suggest that selective serotonin reuptakeinhibitors (SSRIs) modulate emotional processing via earlier changes inattention. However, many previous studies have provided inconsistentfindings. One possible reason for such inconsistencies is that these studiesdid not control for the influence of either sex or sex hormone fluctuations.To address this inconsistency, we administered 20 mg escitalopram orplacebo for seven consecutive days in a randomized, double-blind, placebocontrolleddesign to sixty healthy female participants with a minimum of 3months oral contraceptive (OC) intake. Participants performed a modifiedversion of an emotional flanker task before drug administration, after a singledose, after 1 week of SSRI intake, and after a 1-month wash-out period.Supported by Bayesian analyses, our results do not suggest a modulatoryeffect of escitalopram on behavioral measures of early attentional-emotionalinteraction in female individuals with regular OC use. While the specificconditions of our task may be a contributing factor, it is also possible thata practice effect in a healthy sample may mask the effects of escitalopramon the attentional-emotional interplay. Consequently, 1 week of escitalopramadministration may not modulate attention toward negative emotionaldistractors outside the focus of attention in healthy female participants takingOCs. While further research in naturally cycling females and patient samplesis needed, our results represent a valuable contribution toward the preclinicalinvestigation of antidepressant treatment.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)