Freund, Anne
[Author];
van Royen, Niels
[Author];
Kern, Karl B.
[Author];
Jobs, Alexander
[Author];
Thiele, Holger
[Author];
Lemkes, Jorrit S.
[Author];
Desch, Steffen
[Author]
Early coronary angiography in patients after out‐of‐hospital cardiac arrest without ST‐segment elevation
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Media type:
E-Article
Title:
Early coronary angiography in patients after out‐of‐hospital cardiac arrest without ST‐segment elevation
:
Meta‐analysis of randomized controlled trials
Contributor:
Freund, Anne
[Author];
van Royen, Niels
[Author];
Kern, Karl B.
[Author];
Jobs, Alexander
[Author];
Thiele, Holger
[Author];
Lemkes, Jorrit S.
[Author];
Desch, Steffen
[Author]
imprint:
Hoboken: Wiley, [2024]
Published in:Catheterization and Cardiovascular Interventions ; 100 (2022), Seite 330-337
Description:
Objectives: To compare early coronary angiography to a delayed or selectiveapproach in out‐of‐hospital cardiac arrest (OHCA) without ST‐segment elevation ofpossible cardiac cause by means of meta‐analysis of available randomized controlledtrials (RCTs).Methods: We searched MEDLINE and the Cochrane Central Register of ControlledTrials for RCTs comparing early with delayed or selective coronary angiography inOHCA patients of possible cardiac origin without ST‐segment elevation. The primaryendpoint was all‐cause short‐term mortality (PROSPERO CRD42021271484).Results: The search strategy identified three RCTs enrolling a total of 1167 patients. Anearly invasive approach was not associated with improved short‐term mortality (oddsratio 1.19, 95% confidence interval 0.94–1.52; p = 0.15). Further, no significantdifferences were shown with respect to the risk of severe neurological deficit, thecomposite of all‐cause mortality or severe neurological deficit, need for renal replacementtherapy due to acute renal failure, and significant bleeding at short‐term follow‐up.Conclusion: Early coronary angiography in OHCA without ST‐segment elevation isnot superior compared to a delayed/selective approach.