Wilbring, Manuel
[Author];
Kappert, Utz
[Author];
Haussig, Stephan
[Author];
Winata, Johan
[Author];
Matschke, Klaus
[Author];
Mangner, Norman
[Author];
Arzt, Sebastian
[Author];
Alexiou, Konstantin
[Author]
Hemodynamic Follow-Up after Valve-in-Valve TAVR for Failed Aortic Bioprosthesis
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Media type:
E-Article
Title:
Hemodynamic Follow-Up after Valve-in-Valve TAVR for Failed Aortic Bioprosthesis
Contributor:
Wilbring, Manuel
[Author];
Kappert, Utz
[Author];
Haussig, Stephan
[Author];
Winata, Johan
[Author];
Matschke, Klaus
[Author];
Mangner, Norman
[Author];
Arzt, Sebastian
[Author];
Alexiou, Konstantin
[Author]
Footnote:
Hinweis: Link zum Artikel der zuerst in der Zeitschrift 'Journal of cardiac surgery' bei Wiley erschienen ist. DOI: 10.1111/jocs.17048
Description:
Background
“valve-in-valve” TAVR (VIV-TAVR) is established and provides good initial clinical and hemodynamic outcomes. Lacking long-term durability data baffle the expand to lower risk patients. For those purposes, the present study adds a hemodynamic 3-years follow-up.
Methods
A total of 77 patients underwent VIV-TAVR for failing aortic bioprosthesis during a 7-years period. Predominant mode of failure was stenosis in 87.0%. Patients had a mean age of 79.4 ± 5.8 years and a logistic EuroSCORE of 30.8 ± 15.7%. The Society of Thoracic Surgeons-PROM averaged 5.79 ± 2.63%. Clinical results and hemodynamic outcomes are reported for 30-days, 1-, 2-, and 3-years. Completeness of follow-up was 100% with 44 patients at risk after 3-years. Follow-up ranged up to 7.1 years.
Results
Majority of the surgical valves were stented (94.8%) with a mean labeled size of 23.1 ± 2.3 mm and true-ID of 20.4 ± 2.6 mm. A true-ID ≤21 mm had 58.4% of the patients. Self-expanding valves were implanted in 68.8% (mean labeled size 24.1 ± 1.8 mm) and balloon-expanded in 31.2% (mean size 24.1 ± 1.8 mm). No patient died intraoperatively. Hospital mortality was 1.3% and three-years survival 57.1%. All patients experienced an initial significant dPmean-reduction to 16.8 ± 7.1 mmHg. After 3-years mean dPmean raised to 26.0 ± 12.2 mmHg. This observation was independent from true-ID or type of transcatheter aortic valve replacement (TAVR)-prosthesis. Patients with a true-ID ≤21 mm had a higher initial (18.3 ± 5.3 vs. 14.9 ± 7.1 mmHg; p = .005) and dPmean after 1-year (29.2 ± 8.2 vs. 13.0 ± 6.7 mmHg; p = .004). There were no significant differences in survival.
Conclusions
VIV-TAVR is safe and effective in the early period. In surgical valves with a true-ID ≤21 mm inferior hemodynamic and survival outcomes must be expected. Nonetheless, also patients with larger true-IDs showed steadily increasing transvalvular gradients. This raises concern about durability.