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Markmeyer, Paulina [Author]; Lochmann, Franziska [Author]; Singh, Kunal Kumar [Author]; Gupta, Anubhuti [Author]; Younis, Ruaa [Author]; Shahzad, Khurrum [Author]; Biemann, Ronald [Author]; Huebner, Hanna [Author]; Ruebner, Matthias [Author]; Isermann, Berend [Author]; Kohli, Shrey [Author]

Procoagulant Extracellular Vesicles Alter Trophoblast Differentiation inMice by a Thrombo-InflammatoryMechanism

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  • Media type: E-Article
  • Title: Procoagulant Extracellular Vesicles Alter Trophoblast Differentiation inMice by a Thrombo-InflammatoryMechanism
  • Contributor: Markmeyer, Paulina [Author]; Lochmann, Franziska [Author]; Singh, Kunal Kumar [Author]; Gupta, Anubhuti [Author]; Younis, Ruaa [Author]; Shahzad, Khurrum [Author]; Biemann, Ronald [Author]; Huebner, Hanna [Author]; Ruebner, Matthias [Author]; Isermann, Berend [Author]; Kohli, Shrey [Author]
  • Published: Basel: MDPI, [2024]
  • Published in: International Journal of Molecular Sciences ; 22,18, (2021)
  • Language: English
  • DOI: 10.3390/ijms22189873
  • Keywords: extracellular vesicles ; thrombo-inflammation ; inflammasome ; trophoblast differentiation
  • Origination:
  • Footnote:
  • Description: Procoagulant extracellular vesicles (EV) and platelet activation have been associatedwith gestational vascular complications. EV-induced platelet-mediated placental inflammasomeactivation has been shown to cause preeclampsia-like symptoms in mice. However, the effect ofEV-mediated placental thrombo-inflammation on trophoblast differentiation remains unknown. Here,we identify that the EV-induced thrombo-inflammatory pathway modulates trophoblast morphologyand differentiation. EVs and platelets reduce syncytiotrophoblast differentiation while increasinggiant trophoblast and spongiotrophoblast including the glycogen-rich cells. These effects are plateletdependentand mediated by the NLRP3 inflammasome. In humans, inflammasome activation wasnegatively correlated with trophoblast differentiation marker GCM1 and positively correlated withblood pressure. These data identify a crucial role of EV-induced placental thrombo-inflammation onaltering trophoblast differentiation and suggest platelet activation or inflammasome activation as atherapeutic target in order to achieve successful placentation.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)