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Neuchel, Christine [Author]; Gowdavally, Sowmya [Author]; Tsamadou, Chrysanthi [Author]; Platzbecker, Uwe [Author]; Sala, Elisa [Author]; Wagner-Drouet, Eva [Author]; Valerius, Thomas [Author]; Kröger, Nicolaus [Author]; Wulf, Gerald [Author]; Einsele, Hermann [Author]; Thurner, Lorenz [Author]; Schaefer-Eckart, Kerstin [Author]; Freitag, Sebastian [Author]; Casper, Jochen [Author]; Dürholt, Mareike [Author]; Kaufmann, Martin [Author]; Hertenstein, Bernd [Author]; Klein, Stefan [Author]; Ringhoffer, Mark [Author]; Frank, Sandra [Author]; Amann, Elisa Maria [Author]; Rode, Immanuel [Author]; Schrezenmeier, Hubert [Author]; Mytilineos, Joannis [Author];

Higher risk for chronic graft-versus-host disease (GvHD) in HLA-G mismatched transplants following allogeneic hematopoietic stem cell transplantation

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  • Media type: E-Article
  • Title: Higher risk for chronic graft-versus-host disease (GvHD) in HLA-G mismatched transplants following allogeneic hematopoietic stem cell transplantation : A retrospective study
  • Contributor: Neuchel, Christine [Author]; Gowdavally, Sowmya [Author]; Tsamadou, Chrysanthi [Author]; Platzbecker, Uwe [Author]; Sala, Elisa [Author]; Wagner-Drouet, Eva [Author]; Valerius, Thomas [Author]; Kröger, Nicolaus [Author]; Wulf, Gerald [Author]; Einsele, Hermann [Author]; Thurner, Lorenz [Author]; Schaefer-Eckart, Kerstin [Author]; Freitag, Sebastian [Author]; Casper, Jochen [Author]; Dürholt, Mareike [Author]; Kaufmann, Martin [Author]; Hertenstein, Bernd [Author]; Klein, Stefan [Author]; Ringhoffer, Mark [Author]; Frank, Sandra [Author]; Amann, Elisa Maria [Author]; Rode, Immanuel [Author]; Schrezenmeier, Hubert [Author]; Mytilineos, Joannis [Author];
  • Published: Oxford: Wiley, [2024]
  • Published in: HLA ; 100,4, (2022)
  • Language: English
  • DOI: 10.1111/tan.14733
  • Keywords: HLA-G ; cell transplantation
  • Origination:
  • Footnote:
  • Description: Graft-versus-host disease (GvHD) is a major complicationafter allogeneic hematopoietic stem cell transplantation (allo-HSCT) and ishighly influenced by the degree of HLA matching between recipient anddonor. The HLA-class Ib molecule HLA-G has been shown to promote tolerogenicitythrough its interaction with inhibitory receptors found on severalimmunocompetent cells. We hypothesized that in an allo-HSCT setting,HLA-G mismatches may negatively impact the HLA-G-mediated tolerogenicityeither due to inefficient interaction with the inhibitory receptors of thetransplanted immune cells or due to direct allorecognition of mismatchedHLA-G on host cells by the immune cells of the donor.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)