Description:
<jats:title>Abstract</jats:title><jats:p><jats:bold>Backgrounds and Aim: </jats:bold> Clarithromycin (CAM)‐resistant <jats:italic>Helicobacter pylori</jats:italic> sometimes offers serious problems with eradication by antibiotics. The aim of this study was to determine whether a probiotic can be an alternative therapy in CAM‐resistant Hp infection.</jats:p><jats:p><jats:bold>Methods: </jats:bold> The effects <jats:italic>of Lactobacillus gasseri</jats:italic> (strain OLL2716) on the growth of CAM‐susceptible and CAM‐resistant <jats:italic>H. pylori</jats:italic> and interleukin (IL)‐8 production provoked by these strains were examined by <jats:italic>in vitro</jats:italic> experiments. Moreover, mice were infected with these CAM‐susceptible or CAM‐resistant <jats:italic>H. pylori</jats:italic>, and were treated with CAM or <jats:italic>L. gasseri</jats:italic>.</jats:p><jats:p><jats:bold>Results: </jats:bold> <jats:italic>In vitro</jats:italic> experiments demonstrated that <jats:italic>L. gasseri</jats:italic> inhibited the growth of <jats:italic>H. pylori</jats:italic> and suppressed <jats:italic>H. pylori</jats:italic>‐associated IL‐8 production. Such effects were noted in CAM‐resistant and CAM‐susceptible <jats:italic>H. pylori</jats:italic>. Similarly, in an <jats:italic>in vivo</jats:italic> model of <jats:italic>H. pylori</jats:italic> infection, <jats:italic>H. pylori</jats:italic> colonization was significantly decreased by <jats:italic>L. gasseri</jats:italic>.</jats:p><jats:p><jats:bold>Conclusion: </jats:bold> Therefore, <jats:italic>L. gasseri</jats:italic> was found to act as a probiotic in CAM‐resistant <jats:italic>H. pylori</jats:italic> infection.</jats:p>