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Media type:
E-Article
Title:
Effectiveness of High-intensity Focused Ultrasound (HIFU) Therapy of
Solid and Complex Benign Thyroid Nodules – A Long-term Follow up
Two-center Study
Contributor:
Fischer, Anne;
Korkusuz, Hüdayi;
Vorländer, Christian
imprint:
Georg Thieme Verlag KG, 2022
Published in:Experimental and Clinical Endocrinology & Diabetes
Description:
<jats:title>Abstract</jats:title><jats:p>
Purpose To investigate the effectiveness of high-intensity focused
ultrasound (HIFU) of solid and complex benign thyroid nodules.</jats:p><jats:p>
Methods Fifty-eight patients with benign thyroid nodules were treated with
HIFU at two centers from 2014–2019. The device, EchoPulse (Teraclion,
Malakoff, France), heats the nodes to 80–90 °C. Nodal volumes
were measured by ultrasound at regular intervals before and up to 12 months
after therapy. In a retrospective long-term two-center study, average volume
reductions in relation to baseline volume were statistically analyzed by the
Wilcoxon signed-rank test. Side effects were documented.</jats:p><jats:p>
Results In solid nodules, the average percent volume reductions at the 3,
6, 9, and 12-months follow-up were 49.98%, 46.40%,
65.77%, and 63.88%, respectively. The results were significant
with p<0.05 in the Wilcoxon signed-rank test at the 3, 6, and 9-months
follow-up. In complex nodules, the average percent volume reduction was
35.2% at 3 months, 36.89% at 6 months, and 63.64% at
twelve months follow up. The results were significant with p<0.05 in the
Wilcoxon signed-rank test at the 3- and 6-months follow-up. The complication
rate was 5.2%. All complications occurred in patients with solid
nodules.</jats:p><jats:p>
Conclusion The study showed that HIFU is an effective treatment method for
both solid and complex nodules. The complication rate is relatively high at
5.2%. No long-term complications occurred. The solid nodules responded
better to HIFU than complex nodules.</jats:p>