• Media type: E-Article
  • Title: Suzuki–Miyaura Cross-Couplings under Acidic Conditions
  • Contributor: Pruschinski, Lucas; Lücke, Ana-Luiza; Freese, Tyll; Kahnert, Sean-Ray; Mummel, Sebastian; Schmidt, Andreas
  • imprint: Georg Thieme Verlag KG, 2020
  • Published in: Synthesis
  • Language: English
  • DOI: 10.1055/s-0039-1691487
  • ISSN: 0039-7881; 1437-210X
  • Keywords: Organic Chemistry ; Catalysis
  • Origination:
  • Footnote:
  • Description: <jats:p>Suzuki–Miyaura reactions with Pd(PPh3)4 have been carried out using lithium N-phenylsydnone-4-carboxylate as additive, which gave best yields at pH 5.7 in a mixture of acetic acid, water, and sodium carbonate. Reaction parameters such as the Pd source, the solvent, reaction time and temperature, acid, base and carboxylate have been varied and some representative examples of the Suzuki–Miyaura reaction have been examined.</jats:p>