You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
A PASE Approach to the Synthesis of Benzimidazopurines as Polycondensed Purine Derivatives
Contributor:
Fedotov, Victor V.;
Ulomsky, Evgeny N.;
Savateev, Konstantin V.;
Mukhin, Evgeny M.;
Gazizov, Denis A.;
Gorbunov, Evgeny B.;
Rusinov, Vladimir L.
Published:
Georg Thieme Verlag KG, 2020
Published in:
Synthesis, 52 (2020) 23, Seite 3622-3631
Language:
English
DOI:
10.1055/s-0040-1707228
ISSN:
0039-7881;
1437-210X
Origination:
Footnote:
Description:
A highly efficient PASE approach to a new class of polycyclic purine derivatives has been proposed. The strategy includes a consecutive reduction, auto-aromatization, and heterocyclization of the initial nitrobenzimidazopyrimidines obtained by a three-component condensation. It was shown that reduction of nitrobenzimidazopyrimidines by metals in acidic media was more efficient than heterogeneous hydrogenation. Novel derivatives of benz[4,5]imidazo[1,2-a]purines were obtained in good yields and the proposed structure was confirmed by X-ray crystal structure analysis. The obtained convergent benzimidazopurines combine two relevant medicinal chemistry scaffolds – benzimidazole and purine.