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d’Alessandro, Elisa; Becker, Christian; Bergmeier, Wolfgang; Bode, Christoph; Bourne, Joshua H.; Brown, Helena; Buller, Harry R.; ten Cate-Hoek, Arina J.; ten Cate, Vincent; van Cauteren, Yvonne J. M.; Cheung, Yam F. H.; Cleuren, Audrey; Coenen, Danielle; Crijns, Harry J. G. M.; de Simone, Ilaria; Dolleman, Sophie C.; Klein, Christine Espinola; Fernandez, Delia I.; Granneman, Lianne; van t Hof, Arnoud; Henke, Peter; Henskens, Yvonne M. C.; Huang, Jingnan; Jennings, Lisa K.; [...]

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

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  • Media type: E-Article
  • Title: Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis
  • Contributor: d’Alessandro, Elisa; Becker, Christian; Bergmeier, Wolfgang; Bode, Christoph; Bourne, Joshua H.; Brown, Helena; Buller, Harry R.; ten Cate-Hoek, Arina J.; ten Cate, Vincent; van Cauteren, Yvonne J. M.; Cheung, Yam F. H.; Cleuren, Audrey; Coenen, Danielle; Crijns, Harry J. G. M.; de Simone, Ilaria; Dolleman, Sophie C.; Klein, Christine Espinola; Fernandez, Delia I.; Granneman, Lianne; van t Hof, Arnoud; Henke, Peter; Henskens, Yvonne M. C.; Huang, Jingnan; Jennings, Lisa K.; [...]
  • Published: Georg Thieme Verlag KG, 2020
  • Published in: Thrombosis and Haemostasis, 120 (2020) 4, Seite 538-564
  • Language: English
  • DOI: 10.1055/s-0040-1708035
  • ISSN: 0340-6245; 2567-689X
  • Origination:
  • Footnote:
  • Description: AbstractThrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.