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Media type:
E-Article
Title:
Label-free isolation of circulating tumor cells in microfluidic devices: Current research and perspectives
Contributor:
Cima, Igor;
Wen Yee, Chay;
Iliescu, Florina S.;
Min Phyo, Wai;
Hon Lim, Kiat;
Iliescu, Ciprian;
Han Tan, Min
Published:
AIP Publishing, 2013
Published in:
Biomicrofluidics, 7 (2013) 1
Language:
English
DOI:
10.1063/1.4780062
ISSN:
1932-1058
Origination:
Footnote:
Description:
This review will cover the recent advances in label-free approaches to isolate and manipulate circulating tumor cells (CTCs). In essence, label-free approaches do not rely on antibodies or biological markers for labeling the cells of interest, but enrich them using the differential physical properties intrinsic to cancer and blood cells. We will discuss technologies that isolate cells based on their biomechanical and electrical properties. Label-free approaches to analyze CTCs have been recently invoked as a valid alternative to “marker-based” techniques, because classical epithelial and tumor markers are lost on some CTC populations and there is no comprehensive phenotypic definition for CTCs. We will highlight the advantages and drawbacks of these technologies and the status on their implementation in the clinics.