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Media type:
E-Article
Title:
Protein detection with magnetic nanoparticles in a rotating magnetic field
Contributor:
Dieckhoff, Jan;
Lak, Aidin;
Schilling, Meinhard;
Ludwig, Frank
Published:
AIP Publishing, 2014
Published in:
Journal of Applied Physics, 115 (2014) 2
Language:
English
DOI:
10.1063/1.4861032
ISSN:
0021-8979;
1089-7550
Origination:
Footnote:
Description:
A detection scheme based on magnetic nanoparticle (MNP) dynamics in a rotating magnetic field for a quantitative and easy-to-perform detection of proteins is illustrated. For the measurements, a fluxgate-based setup was applied, which measures the MNP dynamics, while a rotating magnetic field is generated. The MNPs exhibit single iron oxide cores of 25 nm and 40 nm diameter, respectively, as well as a protein G functionalized shell. IgG antibodies were utilized as binding target molecules for the physical proof-of-concept. The measurement results were fitted with a theoretical model describing the magnetization dynamics in a rotating magnetic field. The established detection scheme allows quantitative determination of proteins even at a concentration lower than of the particles. The observed differences between the two MNP types are discussed on the basis of logistic functions.