• Media type: E-Article
  • Title: Inferring network mechanisms: The Drosophila melanogaster protein interaction network
  • Contributor: Middendorf, Manuel; Ziv, Etay; Wiggins, Chris H.
  • imprint: Proceedings of the National Academy of Sciences, 2005
  • Published in: Proceedings of the National Academy of Sciences
  • Language: English
  • DOI: 10.1073/pnas.0409515102
  • ISSN: 1091-6490; 0027-8424
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:p> Naturally occurring networks exhibit quantitative features revealing underlying growth mechanisms. Numerous network mechanisms have recently been proposed to reproduce specific properties such as degree distributions or clustering coefficients. We present a method for inferring the mechanism most accurately capturing a given network topology, exploiting discriminative tools from machine learning. The <jats:italic>Drosophila melanogaster</jats:italic> protein network is confidently and robustly (to noise and training data subsampling) classified as a duplication–mutation–complementation network over preferential attachment, small-world, and a duplication–mutation mechanism without complementation. Systematic classification, rather than statistical study of specific properties, provides a discriminative approach to understand the design of complex networks. </jats:p>
  • Access State: Open Access