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Media type:
E-Article
Title:
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases
Contributor:
Saiardi, Adolfo;
Resnick, Adam C.;
Snowman, Adele M.;
Wendland, Beverly;
Snyder, Solomon H.
imprint:
Proceedings of the National Academy of Sciences, 2005
Published in:Proceedings of the National Academy of Sciences
Language:
English
DOI:
10.1073/pnas.0409322102
ISSN:
0027-8424;
1091-6490
Origination:
Footnote:
Description:
<jats:p>Inositol pyrophosphates physiologically regulate vesicular endocytosis, ribosomal disposition, and directly phosphorylate proteins. Here we demonstrate roles in cell death and regulation of telomere length. Lethal actions of wortmannin and caffeine are selectively abolished in yeast mutants that cannot synthesize inositol pyrophosphates. Wortmannin and caffeine appear to act through the phosphoinositide 3-kinase-related protein kinases Tel1 and Mec1, known regulators of telomere length. Inositol pyrophosphates physiologically antagonize the actions of these kinases, which is demonstrated by the fact that yeast mutants with reduced or elevated levels of inositol pyrophosphates, respectively, display longer and shorter telomeres.</jats:p>