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Media type:
E-Article
Title:
Autologous engineering of cartilage
Contributor:
Emans, Pieter J.;
van Rhijn, Lodewijk W.;
Welting, Tim J. M.;
Cremers, Andy;
Wijnands, Nina;
Spaapen, Frank;
Voncken, J. Willem;
Shastri, V. Prasad
imprint:
Proceedings of the National Academy of Sciences, 2010
Published in:Proceedings of the National Academy of Sciences
Description:
<jats:p>Treatment of full-thickness damage to hyaline cartilage is hampered by the limited availability of autologous healthy cartilage and the lengthy, cost-prohibitive cell isolation and expansion steps associated with autologous cartilage implantation (ACI). Here we report a strategy for de novo engineering of ectopic autologous cartilage (EAC) within the subperiosteal space (in vivo bioreactor), through the mere introduction of a biocompatible gel that might promote hypoxia-mediated chondrogenesis, thereby effectively overcoming the aforementioned limitations. The EAC is obtained within 3 wk post injection of the gel, and can be press-fit into an osteochondral defect where it undergoes remodeling with good lateral and subchondral integration. The implanted EAC showed no calcification even after 9 mo and attained an average O’Driscoll score of 11 (versus 4 for controls). An “on demand” autologous source of autologous cartilage with remodeling capacity is expected to significantly impact the clinical options in repair of trauma to articular cartilage.</jats:p>