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Media type:
E-Article
Title:
Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages
Contributor:
Dearnley, Megan;
Chu, Trang;
Zhang, Yao;
Looker, Oliver;
Huang, Changjin;
Klonis, Nectarios;
Yeoman, Jeff;
Kenny, Shannon;
Arora, Mohit;
Osborne, James M.;
Chandramohanadas, Rajesh;
Zhang, Sulin;
Dixon, Matthew W. A.;
Tilley, Leann
Published:
Proceedings of the National Academy of Sciences, 2016
Published in:
Proceedings of the National Academy of Sciences, 113 (2016) 17, Seite 4800-4805
Language:
English
DOI:
10.1073/pnas.1520194113
ISSN:
0027-8424;
1091-6490
Origination:
Footnote:
Description:
<jats:title>Significance</jats:title>
<jats:p>
This study provides, to our knowledge, the first ultrastructural and dynamics analysis of the host red blood cell membrane of
<jats:italic>Plasmodium falciparum</jats:italic>
gametocytes, revealing reversible expansion of the spectrin–actin skeleton, accompanied by reversible modulation of skeletal coupling to the plasma membrane. We use the measured physical parameters to inform a computationally efficient coarse-grained model. This model shows that restructuring the skeletal meshwork can fully account for the observed deformability changes. We reveal a critical role for actin remodeling in driving this reversible biomechanical host cell subversion. This work provides fundamental insights into the molecular changes that underpin gametocyte survival in the circulation.
</jats:p>