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Media type:
E-Article
Title:
Comparative genome-scale modelling of Staphylococcus aureus strains identifies strain-specific metabolic capabilities linked to pathogenicity
Contributor:
Bosi, Emanuele;
Monk, Jonathan M.;
Aziz, Ramy K.;
Fondi, Marco;
Nizet, Victor;
Palsson, Bernhard Ø.
imprint:
Proceedings of the National Academy of Sciences, 2016
Published in:Proceedings of the National Academy of Sciences
Language:
English
DOI:
10.1073/pnas.1523199113
ISSN:
0027-8424;
1091-6490
Origination:
Footnote:
Description:
<jats:title>Significance</jats:title>
<jats:p>
Comparative analysis of multiple strains within a species is a powerful way to uncover pathoadaptive genetic acquisitions. Hundreds of genome sequences are now available for the human pathogen
<jats:italic>Staphylococcus aureus,</jats:italic>
mostly known for its antibiotic-resistant variants that threaten the emergence of panresistant superbugs. In this study, genome-scale models of metabolism are used to analyze the shared and unique metabolic capabilities of this pathogen and its strain-specific variants. The models are used to distinguish
<jats:italic>S. aureus</jats:italic>
strains responsible for severe infections based solely on growth capabilities and presence of different virulence factors. The results identify metabolic similarities and differences between
<jats:italic>S. aureus</jats:italic>
strains that provide insights into the epidemiology of
<jats:italic>S. aureus</jats:italic>
and may help to combat its spread.
</jats:p>