Description:
<jats:title>Significance</jats:title>
<jats:p>Fungi produce a vast number of different chemical compounds via secondary metabolism. These compounds are of great interest because of their potential applicability in medicine, pharmacy, and biotechnology. In addition, a number of such compounds are toxins that potentially represent severe threats to human and animal health. However, under standard cultivation conditions, fungal secondary metabolism remains largely inactive. Here, we show that the deletion of the regulator Xylanase promoter binding protein 1 (Xpp1) results in the production of significantly more secondary metabolites in terms of both number and concentration. Because homologs of Xpp1 exist in fungi with numerous bioactive secondary metabolites, our results can lead to the discovery of secondary metabolites.</jats:p>